| Name | 3-Amino-1,2,4-triazole |
| Description | 3-Amino-1,2,4-triazole (Trapidil impurity B) is an inhibitor of catalase, capable of inducing the compensatory mechanism for hydrogen peroxide detoxification. This mechanism involves increasing the activities of glutathione peroxidase and glutathione reductase. |
| In vitro | 3-Amino-1,2,4-triazole (1,10 and 100 microg/ml ) had no significant cytotoxicity to the FRTL-5 cells (P > 0.05). The concentration of thyroglobulin (TG) in the culture was decreased by 10 and 100 microg/ml 3-Amino-1,2,4-triazole (P < 0.05), and the concentration of TG in the cells was decreased by 100 microg/ml (P < 0.05) but the TTF-1 in the cells were not obviously changed (P > 0.05). The TSHR in the surface of FRTL-5 cells was significantly decreased by all doses of 3-Amino-1,2,4-triazole (P < 0.01). The influence of 3-Amino-1,2,4-triazole on TG of FRTL-5 cells may be related to significantly reduce TSHR in the surface of FRTL-5 cells.[1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility Information | DMSO : 90 mg/mL (1070.41 mM), Sonication is recommended.
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| Keywords | ReactiveOxygenSpecies | Reactive Oxygen Species | Catalase | 3-Amino-1,2,4-triazole |
| Inhibitors Related | Cysteamine hydrochloride | Acetylcysteine | Imeglimin hydrochloride | L-Ascorbic acid | Hesperidin | Glucosamine | Coenzyme Q10 | L-Ascorbic acid sodium salt | Sodium 2-oxopropanoate | Naringenin | Uric Acid | Quercetin |
| Related Compound Libraries | Pesticide Compound Library | Bioactive Compound Library | Anti-Ovarian Cancer Compound Library | Anti-Obesity Compound Library | Inhibitor Library | Mitochondria-Targeted Compound Library | Metabolism Compound Library | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Oxidation-Reduction Compound Library |
United States
