2-Iodoxybenzoic acid NEW

As an oxidizing agent, the oxidizing properties of primary and secondary alcohols in DMSO are similar to those of DMP, and IBX has better selectivity than DMP when alcohols have multiple functional groups. In addition, DMP is unstable, cannot be stored for a long time, and must be prepared before use, which is very inconvenient to use.

2-Iodoxybenzoic acid is used for oxidation of alcohols in organic synthesis. It is also often used in the preparation of Dess-Martin iodoxin.

2-Iodoxybenzoic acid is a cheap, mild oxidizing agent, easy to prepare, has better selectivity than DMP, and can also be used to prepare lipid and protein metabolism improver oxandrone. The oxidation reaction of IBX to alcohols is usually carried out in DMSO or DMSO/THF solution. By simply heating the mixture of alcohol, IBX and organic solvents such as ethyl acetate, chloroform, benzene, acetonitrile, acetone, dichloromethane, etc., the primary and secondary alcohols can be oxidized to the corresponding aldehydes and ketones. After the reaction, the insoluble byproducts and solvents were removed by filtration to obtain the corresponding carbonyl compounds.