2-Chlorotrityl chloride NEW

$1.00 1000KG

$100.00 1KG

Henan Fengda Chemical Co., Ltd

1YR

China

Chemical Properties

Product Name	2-Chlorotrityl chloride
CAS No	42074-68-0
EC-No
Min. Order	1KG
Purity	99%
Supply Ability	g-kg-tons, free sample is available
Release date	2023/12/26

1. Product information

2-Chlorotrityl chloride Chemical Properties

Melting point	130-135 °C
Boiling point	421.3±40.0 °C(Predicted)
density	1.222±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	Soluble in Chloroform, methanol and dichloromethane, insoluble in water
form	Powder
color	Pale yellow crystalline powder

2-Chlorotrityl chloride Usage And Synthesis

Chemical Properties	off-white to yellow or brown beads
Uses	2-Chlorotrityl chloride is used as an intermediate of clotrimazole. It is also used in the preparation of modified trityl nucleosides as inhibitors of P. falciparum dUTPase. In addition, it serves as a protecting group reagent for carboxylic acids forming esters.
Application	2-Chlorotrityl Chloride is used in convergent peptide synthesis. Extremely acid labile resin for preparing peptide acids and partially protected peptide fragments by the Fmoc strategy. Cleavage can be effected by using AcOH/TFE/DCM or 0.5% TFA.
Preparation	2-Chlorotrityl chloride synthesis: It is esterified with 2-Chlorobenzoic acid and ethanol in the presence of sulfuric acid or p-toluenesulfonic acid to generate Ethyl 2-Chlorobenzoate, which is then condensed with phenylmagnesium bromide (Grignard reaction) to obtain (2-Chlorophenyl)diphenylmethanol magnesium salt is hydrolyzed with sulfuric acid to obtain (2-Chlorophenyl)diphenylmethanol, which is then chlorinated with thionyl chloride to obtain the product.

2. Packaging

For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.

For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product.

Or smaller package 1kg/bottle, 10kgs/bottle as request.