2-Aminothiazole NEW

• MOLECULAR FORMULA :

• C3-H4-N2-S

• MOLECULAR WEIGHT :

• 100.15

• WISWESSER LINE NOTATION :

• T5N CSJ BZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - rat

• DOSE/DURATION :

• 480 mg/kg

• TOXIC EFFECTS :

• Behavioral - tremor Behavioral - coma Lungs, Thorax, or Respiration - dyspnea

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Intravenous

• SPECIES OBSERVED :

• Rodent - rat

• DOSE/DURATION :

• 570 mg/kg

• TOXIC EFFECTS :

• Details of toxic effects not reported other than lethal dose value

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Intraperitoneal

• SPECIES OBSERVED :

• Rodent - mouse

• DOSE/DURATION :

• 200 mg/kg

• TOXIC EFFECTS :

• Details of toxic effects not reported other than lethal dose value

• TYPE OF TEST :

• LDLo - Lowest published lethal dose

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Mammal - cat

• DOSE/DURATION :

• 120 mg/kg

• TOXIC EFFECTS :

• Behavioral - tremor Behavioral - coma Lungs, Thorax, or Respiration - dyspnea

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - rabbit

• DOSE/DURATION :

• 370 mg/kg

• TOXIC EFFECTS :

• Behavioral - tremor Behavioral - coma Lungs, Thorax, or Respiration - dyspnea

• TYPE OF TEST :

• LDLo - Lowest published lethal dose

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - guinea pig

• DOSE/DURATION :

• 120 mg/kg

• TOXIC EFFECTS :

• Behavioral - tremor Behavioral - coma Lungs, Thorax, or Respiration - dyspnea

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - rabbit

• DOSE/DURATION :

• 4500 mg/kg/56D-I

• TOXIC EFFECTS :

• Liver - hepatitis (hepatocellular necrosis), zonal Liver - fatty liver degeneration Related to Chronic Data - death

• TYPE OF TEST :

• TCLo - Lowest published toxic concentration

• ROUTE OF EXPOSURE :

• Inhalation

• SPECIES OBSERVED :

• Rodent - rabbit

• DOSE/DURATION :

• 200 mg/m3/7H/61D-I

• TOXIC EFFECTS :

• Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis) Lungs, Thorax, or Respiration - dyspnea Related to Chronic Data - death

• TYPE OF TEST :

• TCLo - Lowest published toxic concentration

• ROUTE OF EXPOSURE :

• Inhalation

• SPECIES OBSERVED :

• Rodent - guinea pig

• DOSE/DURATION :

• 200 mg/m3/7H/30D-I

• TOXIC EFFECTS :

• Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - chronic pulmonary edema Related to Chronic Data - death

• TYPE OF TEST :

• TCLo - Lowest published toxic concentration

• ROUTE OF EXPOSURE :

• Inhalation

• SPECIES OBSERVED :

• Rodent - guinea pig

• DOSE/DURATION :

• 25 mg/m3/7H/62D-I

• TOXIC EFFECTS :

• Lungs, Thorax, or Respiration - chronic pulmonary edema Liver - fatty liver degeneration Related to Chronic Data - death

MUTATION DATA

• TYPE OF TEST :

• Mutation in mammalian somatic cells

• TEST SYSTEM :

• Rodent - mouse Lymphocyte

• DOSE/DURATION :

• 557 mg/L

• REFERENCE :

• MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 155,17,1985