General Description
Light brown crystals or brown granular solid.
Reactivity Profile
2-AMINOTHIAZOLE(96-50-4) reacts violently when nitrated with nitric or nitric-sulfuric acids. 2-AMINOTHIAZOLE(96-50-4) is also incompatible with strong oxidizing agents, strong acids, acid chlorides and acid anhydrides.
Air & Water Reactions
Insoluble in water.
Fire Hazard
Flash point data for this chemical are not available; however, 2-AMINOTHIAZOLE is probably combustible.
Chemical Properties
brown crystalline powder, grains, lumps or flakes
Uses
2-Aminothiazole is a heterocyclic amine and is the beginning reagent for the synthesis of many pharmaceutical and agricultural related compounds.
Uses
Usually used in the synthesis of 2-aminothiazole-modified silica gel，and aslo used in Ulmann coupling with 2-chlorobenzoic acids mediated by ultrasonic irradiation.
Definition
ChEBI: A primary amino compound that is 1,3-thiazole substituted by an amino group at position 2.
Biochem/physiol Actions
2-Aminothiazoles are potent cyclin-dependent kinase 5 inhibitors and are therapeutic agents for the treatment of Alzheimer′s disease and other neurodegenerative disorders.
Safety Profile
Poison by ingestion andintraperitoneal routes. Mutation data reported.Spontaneous ignition occurs at 100°. Mixtures with nitricacid or nitric acid + sulfuric acid explode on heating.Incompatible with HNO3 and H2SO4. When heated todecomposition it emi
Purification Methods
It crystallises from pet ether (b 100-120o), or EtOH. [Beilstein 27 III/IV 4574.]
