99% Bulk Tinidazole Powder CAS: 19387-91-8 Pharma Tinidazole
Product description
Usage And Synthesis
The preparation of ethylsulfonylethyl-p-toluenesulfonate is carried out in the following manner: 69.0 grams (0.5 mol) ethylsulfonylethanol dissolved in 150 ml pyridine is cooled to 0°C with stirring and while maintaining the temperature between 0° to 10°C, 95 grams (0.5 mol) p-toluenesulfonyl chloride is added in portions over a 10 minute period. After this time, 250 ml water is added slowly and the mixture extracted with chloroform, the organic phase washed first with 2 N HCl, then with water, separated and dried. The product which crystallizes on cooling is filtered and dried to give 77.5% yield of this intermediate.
A mixture of 12.7 grams (0.1 mol) of 2-methyl-5-nitroimidazole and 58.4 grams (0.2 mol) ethylsulfonylethyl-p-toluenesulfonate is heated with stirring, under nitrogen, at 145° to 150°C for about 4 hours. After this time, the reaction mixture is extracted with 500 ml hot water, the aqueous portion adjusted with 10% Na2CO3 to a pH of 9 and extracted with chloroform (3 times with 150 ml portions). The separated organic phase is washed with water, dried with Na2SO4 and evaporated to dryness. The crude tinidazole product is then crystallized from benzene to give 4.36 grams of product having a MP of 127° to 128°C.
Our Service
1.Cooperate with research institutions, we strictly control the process from raw material to finished product.
2.We can provide the reasonable price, high quality products and prompt shipment.
3.We can send the goods to your delivery address directly. It is relatively safe and fast.
4.Quick and clear response to customers questions, we’ll treat every email and message within 24 hours usually much faster.
5.We can provide you a discount if you place a substantial order with us.
6.Products can be packaged and company logo can be customized according to customer requirements.
Delivery
1. Sent out in 24hours once payment comfirm.
2. Professional agent make sure our ship fastly and safety
3.Offer your tracking number to you once we get it ,in order to facilitateyou track the express.
FAQ
Q1: Can i get some samples?
A: Yes, we can supply the sample, but the shipping cost be paid by ourcustomers.
Q2: How to start orders or make payments?
A: Proforma invoice will be sent first after confirmation of order, enclosedour bank information. Payment by T/T, Western Union or Paypal.
Q3: How to confirm the Product Quality before placing orders?
A:You can get free samples for some products,you only need to pay theshipping cost or arrange a courier to us and take the samples. You cansend us your product specifications and requests,we will manufacture theproducts according to your requests.
Q4:What's your MOQ?
A:Our MOQ is 1kg. But usually we accept less quantity such as 100g onthe condition that sample charge is 100% paid.
Q5: How about delivery lead time?
A:Delivery lead time: About 3-5 days after payment confirmed. (Chineseholiday not included)
Q6: Do You Ship Over The Weekend?
We use EMS,TNT,FEDEX,DHL four kinds of couriers. EMS don't collected parcelsover the weekend. The packages can be shipped out normally before 12:00a.m in Beijing time if you choose to ship by TNT or FedEx.
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