Quick details
Product name: Retinoic acid
Other names all-trans; Retinoic acid; Retinoic acid, all trans
Case of 302-79-4
MF C20H28O2
300.44 mw
The content of 98.0-102.5%
Melting point 179 to 186 degrees Celsius
Boiling point 462.8°Cat 780 mmHg
Water insoluble
Molecular structure Active pharmaceutical intermediate powder Retinoic acid CAS 302-79-4 for the treatment of acne
Assay 99%
Appearance: Orange yellow powder
Cuticle separation, anti - acne, anti - tumor
describe
Retinoic acid is A derivative of vitamin A. It is used on the skin (topically) to treat mild to moderate acne and skin damaged by excessive exposure to the sun
Retinoic acid is the acid form of vitamin A, also known as all-trans retinoic acid or ATRA. It is commonly used to treat acne vulgaris and keratosis pilosa. It can be used as a cream or gel. It is also used to treat acute promyelocytic leukemia. It can also be used as a generic.
Its success in the treatment of acute promyelocytic leukemia is a major breakthrough in the treatment of this type of leukemia. It works in APL because most cases involve chromosomal translocations on chromosomes 15 and 17, which cause the gene for the retinoic acid receptor gene to fuse with the promyelocytic leukemia gene.
This fusion PML-RAR protein is responsible for preventing immature bone marrow cells from differentiating into more mature cells. This blocking of differentiation is thought to lead to leukemia.
Usage:
Retinoic acid is A commonly used drug in dermatology. It is A metabolic intermediate of vitamin A (Victoria methanol). It mainly affects the growth of bone and epithelial metabolism, promotes the proliferation and renewal of epithelial cells, and inhibits the proliferation and differentiation of keratinocytes, so excessive keratosis can be restored to normal. Therefore, it has certain therapeutic effect on many complete or incomplete keratosis and excessive keratosis diseases, and can treat a variety of skin diseases. The use of the drug can quickly penetrate the local skin, resulting in a significant increase in epithelial cell renewal. This kind of drug has strong and rapid inhibition effect on sebaceous gland secretion, can reduce sebum secretion. In addition, the product has anti-tumor, wound healing and anti-inflammatory effects.
Specifications:
Project Specification Results
Description yellow to light orange fine pink yellow crystalline powder
Water soluble
insoluble
Conform to the
Dry weight loss ≤ 0.5% 0.2%
Incandescent residue ≤ 0.1% 0.03%
Heavy metal ≤ 0.002% meets the requirement
Isotretinic acid limit ≤ 5.0% 0.1%
Assay 99% 99.2%
Standard EP7 is met
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