Identification Chemical Properties Safety Data Hazard Information Material Safety Data Sheet(MSDS) Questions And Answer Spectrum Detail Well-known Reagent Company Product Information Supplier Related Products

302-79-4

Name Tretinoin
CAS 302-79-4
EINECS(EC#) 206-129-0
Molecular Formula C20H28O2
MDL Number MFCD00079542
Molecular Weight 300.44
MOL File 302-79-4.mol

Chemical Properties

Appearance Yellow-Orange Powder
Melting point  180-181 °C (lit.)
Boiling point  381.66°C (rough estimate)
density  1.0597 (rough estimate)
refractive index  1.4800 (estimate)
storage temp.  2-8°C
solubility  Practically insoluble in water, soluble in methylene chloride, slightly soluble in ethanol (96 per cent).
form  powder
pka 4.73±0.33(Predicted)
color  yellow
Water Solubility  insoluble
Sensitive  Light Sensitive
Usage Physiological metabolite of vitamin A. Effects gene expression via nuclear retinoic acid receptors (RAR); mediates cellular growth and differentiation
Merck  14,8165
BRN  2057223
Stability: Store Dry in Freezer at -20°C for up to 1 year; in Solution at -20°C for up to 3 Months.
InChIKey SHGAZHPCJJPHSC-ZVCIMWCZSA-N
LogP 6.300
Uses
retinoic acid (tretinoin) is a vitamin A derivative. It has demonstrated an ability to alter collagen synthesis, increase dermal hyaluronic acid levels, and stimulate fibroblast growth and the extracellular matrix. It is used for keratinization disorders and for treating acne. Retinoic acid’s anti-aging effect has been convincingly documented and it is often used for treating the visible signs of aging, though these results can take approximately 6 months to be visible. It is associated with a number of adverse effects, including irritation, photosensitivity, skin dryness, redness, and peeling. It should also not be used while pregnant.
CAS DataBase Reference 302-79-4(CAS DataBase Reference)
EPA Substance Registry System 302-79-4(EPA Substance)

Safety Data

Hazard Codes  T,Xn
Risk Statements 
R22:Harmful if swallowed.
R63:Possible risk of harm to the unborn child.
R38:Irritating to the skin.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
Safety Statements 
S53:Avoid exposure-obtain special instruction before use .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36/37:Wear suitable protective clothing and gloves .
RIDADR  3249
WGK Germany  3
RTECS  VH6475000
7-8-16-23
TSCA  Yes
HazardClass  6.1(b)
PackingGroup  III
HS Code  29362100
Safety Profile
Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. Experimental reproductive effects. Questionable carcinogen with experimental neoplastigenic and teratogenic data. Human mutation data reported. A human skin irritant. When heated to decomposition it emits acrid smoke and irritating fumes. Used to treat acne and other skin problems.
Hazardous Substances Data 302-79-4(Hazardous Substances Data)
Toxicity
LD50 (10 day) in mice, rats (mg/kg): 790, 790 i.p.; 2200, 2000 orally (Kamm)

Hazard Information

Questions And Answer

Well-known Reagent Company Product Information

Supplier