Rosuvastatin Calcium

PRODUCT DETAILS

Rosuvastatin Calcium is a competitive inhibitor of HMG-CoA reductase with IC50 of 11 nM. IC50 Value: 11 nM [1]Target: HMG-CoA reductasein vitro: Rosuvastatin is relatively hydrophilic and is highly selective for hepatic cells; its uptake is mediated by the liver-specific organic anion transporter OATP-C. Rosuvastatin is a high-affinity substrate for OATP-C with apparent association constant of 8.5 μM [2]. Rosuvastatin inhibits cholesterol biosynthesis in rat liver isolated hepatocytes with IC50 of 1.12 nM. Rosuvastatin causes approximately 10 times greater increase of mRNA of LDL receptors than pravastatin [1]. Rosuvastatin (100 μM) decreases the extent of U937 adhesion to TNF-α-stimulated HUVEC. Rosuvastatin inhibits the expressions of ICAM-1, MCP-1, IL-8, IL-6, and COX-2 mRNA and protein levels through inhibition of c-Jun N-terminal kinase and nuclear factor-kB in endothelial cells [3].in vivo: Rosuvastatin (3 mg/kg) daily administration for 14 days decreases plasma cholesterol levels by 26% in male beagle dogs with normal cholesterol levels. In cynomolgus monkeys, Rosuvastatin decreases plasma cholesterol levels by 22% [1]. Rosuvastatin (20 mg/kg/day) administration for 2 weeks, significantly reduces very low-density lipoproteins (VLDL) in diabetes mellitus rats induced by Streptozocin [4]. Rosuvastatin shows antiatherothromhotic effects in vivo. Rosuvastatin (1.25 mg/kg) significantly inhibits thrombin-induced transmigration of monocvtes across mesenteric venules via inhibition of the endothelial cell surface expression of P-selectin, and increases the basal rate of nitric oxide in aortic segments by 2-fold times [5].   

OUR ADVANTAGE
1 high quality,competitive price,good service.
2. It's customers' right to choose the package ;
3.It's customers' right to choose the packing way for his products from many recent effective packing ways
4.Specials are possible when client's order is big enough, including the discount policy;
5.Our company promise to deliver clients' package to his hands safely, or we'll cover the total loss and reship in time.
QUALITY ASSURANCE:
Our products are all made of purest raw materials. With high quality research lab  equipments. The facilities are beyond the competitive suppliers.
We will delivery at once your payment is check and confirmed. The delivery will be by air. will need as short as3 days to get to you. 
SAFE PAYMENT:
We accept payment of PAYPAL/ West Union/ Money Gram. All is for your convenient. So your  payment is ensured. Please don't hesitate to buy form us.
LOWEST PRICE:
We have very good price because of our advanced technology and huge supply of products. But  we accept test samples in very low price.

ABOUT US

HEBEI YINGONG NEW MATERIAL TECHNOLOGY CO.,LTD. is a professional Manufacturer of API&Pharmaceutical intermediates in China. We have a registered capital of 1 million yuan and is one of the most dynamic foreign trade companies in the Chinese market. We have a pharmaceutical raw material production plant and a reagent R&D center. We now have the most complete product line. In addition, we have developed and produced tens of thousands of reagents. We also have the business of custom synthesis of various organic compounds as a supplement. We can synthesize almost all chemicals. Our goal is to survive by quality and develop by credit.

In the past two years, our products have spread over more than 30 countries in the world, Europe, South America, North America, Southeast Asia and Africa. We work with friends all over the world to develop the best quality products, the most reasonable prices and safe and effective transportation. Product can be ordered from milligrams to tons. Meet the purchase of new and old customers. We will not let you down.

PAYMENT METHODS

TT/ Western Union/ MoneyGram/ BTC

TRANSPORTATION METHODS

Express/by sea/ by air (Depends on customer demand)

FAQ
Q1: Can i get some samples?
 A: Yes, we can supply the free sample, but the shipping cost be paid by our customers.
Q2: How to start orders or make payments? 
A: Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T, Western Union,BTC,MoneyGram
Q3: How to confirm the Product Quality before placing orders? 
A:You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.
Q4:What's your MOQ? 
A:Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.
Q5: How about delivery lead time?

A:Delivery lead time: About 3-5 days after payment confirmed. (Chinese holiday not included)

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CONTACT ME

Mail:claire@hbyingong.com

Web:www.hbyingong.com

WhatsApp/pho.:+8619933070948

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