名称 | Rosuvastatin calcium |
描述 | Rosuvastatin calcium (ZD4522) , a selective and competitive inhibitor of hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, has antilipidemic activity. |
体外活性 | In streptozotocin-induced diabetic rats, daily administration of Rosuvastatin (20 mg/kg) significantly reduces the content of very low-density lipoprotein (VLDL) within the body. Similarly, in male beagles with normal cholesterol levels, Rosuvastatin (3 mg/kg) effectively lowers the concentration of cholesterol in the plasma. |
体内活性 | In isolated rat hepatocytes (IC50=1.12 nM), Rosuvastatin acts as a high-affinity substrate for OATP-C, inhibiting cholesterol synthesis. Additionally, in endothelial cells, Rosuvastatin suppresses the expression and protein levels of ICAM-1, MCP-1, IL-8, IL-6, and COX-2 mRNA by inhibiting the c-Jun N-terminal kinase and nuclear factor-kB. |
存储条件 | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
溶解度 | DMSO : 100 mg/mL (199.77 mM), Heating is recommended.
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关键字 | gene | lipoprotein | Inhibitor | ZD-4522 | Rosuvastatin calcium | potential | repolarization | Autophagy | QTc | Hsp70 | related | HMG-CoA Reductase (HMGCR) | inhibit | durations | Potassium Channel | Rosuvastatin | cholesterol | hERG | cardiac | ZD 4522 | low-density | KcsA | triglycerides | action | APDs |
相关产品 | Hydroxychloroquine | Guanidine hydrochloride |
相关库 | 经典已知活性库 | 疼痛相关化合物库 | 膜蛋白靶向化合物库 | 抗癌临床化合物库 | 抗病毒库 | 已知活性化合物库 | 抗癌药物库 |