| Product Name: | Glimepiride |
| CAS: | 93479-97-1 |
| MF: | C24H34N4O5S |
| MW: | 490.62 |
| EINECS: | 642-919-5 |
Glimepirea is a third-generation sulfonylurea long-acting antidiabetic drug. The main mechanism of its hypoglycemic effect is to stimulate the secretion of insulin by pancreatic β cells and partially improve the sensitivity of surrounding tissues to insulin. The combination and dissociation rate of this product with insulin receptor is faster than glyburide, and less severe hypoglycemia. Its mechanism of action is through binding to the sulfonylurea receptor (6.5×104 protein) on the surface of pancreatic β -cells, which is coupled with THE ATP-sensitive K+ (KATP) channel, causing the closure of KATP channel, causing the depolarization of cell membrane, opening the voltage-dependent calcium channel, and promoting the release of insulin by Ga2+ influx. And inhibit the synthesis of hepatic glucose. Recent studies have shown that different sulfonylurea coal drugs have different affinity for KATP. The order was glimepiride > toluensulfonylurea > chlorsulfonylupropirea. In addition, glimepiride increases cardiac glucose uptake through a non-insulin-dependent pathway, possibly due to increased expression of glucose transporter 1,4 proteins. The effect of glimepiride on cardiovascular KATP channel is weaker than that of glibopiride and gliclazide. Therefore, cardiovascular adverse reactions are rare.
Packaging & Shipping
| Quantity(Metric Tons) | 1 - 1 | 2 - 20 | >20 |
| Est. Time(days) | 10 | 25 | To be negotiated |
Company Information
Hebei Lingding Biotechnology Co., Ltd. is a professional business company ,that include pharmaceutical raw materials, pharmaceutical intermediates,and other more than 1000 products of the enterprise, The registered capital is 3 million yuan, it is a collection of scientific research, production and sales in one of the enterprises.
Since its establishment, the company has always adhered to the core concept of "focus on products, attentive service", adhere to the business purpose of "innovation, professional, win-win", to provide customers with a full range of meticulous and thoughtful services. We will adhere to the customer's serious and responsible attitude, comply with the standardized operation procedures, with efficient execution to complete customer needs.
The company's products are sold all over the world, mainly exported to the United States, Europe, Southeast Asia, Australia, the Middle East and South Africa and other countries.The company has a strong scientific research and technical team, can provide customers with high quality products and a full range of services. We will provide first-class products and better service to face the needs of customers, to meet the challenges of the market. Welcome domestic and foreign customers to negotiate.
Our Services
1.Any inquiry or message will be replied within 12 hours.
2.Professional manufacturer. Welcome to visit our website.
3.API, Intermediate are available, we can offer Custom Synthesis, and registration as well.
4.Fast delivery.
5.After-sale services
FAQ
Q1. Are you a manufacturer?
Answer: Yes, we have our own factory.
Q2. Do you have GMP or DMF?
Answer: Yes, we have GMP certificate for some products, and we can provide DMF as well.
Q3. What information should I let you know if I want to get a quotation?
Answer: -Quality you require, eg. Assay, Purity, or single impurity
-Quantity you need
-Standard you want, such as USP, EP, JP etc.
Q4. How to make the payment?
Answer: T/T in advance are highly recommended. We can accept Western Union,
Money Gram and Paypal as well.
Q5. When will you deliver the goods?
Answer: For sample(less than 1kg), in about 3 working days after payment; for larger orders (more than 1kg), in about 7 working days after payment.
Q6. How will you deliver the goods?
Answer: We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS, China Air Post. For container products, we can do sea shipping. You also can choose your own shipping forwarder.
Q7. When will we receive the goods?
Answer: For samples, we will send by TNT/DHL/FEDEX/UPS express, usually it takes about 3-5 to reach you; for larger orders, it will take about 7 -10days at most.
Q8. What if we find your products unsatisfied?
Answer: We will send you a COA (Certificate of Analysis) to you first for you to confirm the quality, but if you find our products not confirm with the COA after you receive it, please show us your test result, we will refund you once we confirm that.
Q9.Do you have stock?
Answer:As we know,most customers prefer stock,so we will try to keep stock for some products.
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