Tacrolimus Powder CAS 104987-11-3 supplier manufacturer in China
Details
Product Name:Tacrolimus
CAS: 104987-11-3
MF: C44H69NO12
MW: 804.02
Melting point: 113-115°C
Fp: 2ºC
Storage temp.: −20°C
Chemical Properties: White Crystalline Solid
What is Tacrolimus?
Tacrolimus (trade names Prograf, Advagraf, Protopic) is animmunosuppressive drug used mainly after allogeneic organ transplant to lower the risk of organ rejection. It achieves this by inhibiting the production of interleukin-2, a molecule that promotes the development andproliferation of T cells, which are vital to the body's learned (or adaptive) immune response. Tacrolimus is also used in the treatment of other T cell-mediated diseases such as eczema (for which it is applied to the skin in a medicated ointment), severe refractory uveitis after bone marrow transplants, exacerbations ofminimal change disease, Kimura's disease, and the skin condition vitiligo.
Tacrolimus is an immunosuppressive drug whose main use is after organ transplant to reduce the activity of the patient's immune system and so the risk of organ rejection. It is also used in a topical preparation in the treatment of severe atopic dermatitis, severe refractory uveitis after bone marrow transplants, and the skin condition vitiligo. It was discovered in 1984 from the fermentation broth of a Japanese soil sample that contained the bacteria Streptomyces tsukubaensis. Tacrolimus is chemically known as a macrolide. It reduces peptidyl-prolyl isomerase activity by binding to the immunophilin FKBP-12 (FK506 binding protein) creating a new complex. This FKBP12-FK506 complex interacts with and inhibits calcineurin thus inhibiting both T-lymphocyte signal transduction and IL-2 transcription.
Uses:
For use after allogenic organ transplant to reduce the activity of the patient's immune system and so the risk of organ rejection. It was first approved by the FDA in 1994 for use in liver transplantation, this has been extended to include kidney, heart.
wickr daisylang
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mia@crovellbio.com
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Package and shipping
25kg paper drum
Company details
Hebei Crovell Biotech Co,.LTD. is the leading manufacturer for cosmetic materials in China.
Which located in Shijiazhuang, Hebei Province.
We are specialized in pharmaceutical intermediates, veterinary drug intermediates and dyes intermediates,
After ten years development, Hebei Crovell Biotech Co,.LTD. has become a Diversified development company, not only involves in chemicals, but also real estate, clothes, agricultural products and so on.
So far, Hebei Crovell Biotech Co,.LTD. has business in more than 35 countries, most big customers come from Europe and America, because among the suppliers in China, Crovell can always make the product quality best, some of the products from Crovell can reach the purity of 99.9+, such as carbomer. This is the important reason for customers who choosing Crovell.
In future, Hebei Crovell Biotech Co,.LTD. must become to a more important trade bridge for China and foreign countries especially in pharmaceutical industries
6.FAQ
1. quality
our products meet msds safe standard and we have iso and other certificate so yan can get high quality products from our company.
2. price
we are the company which is the joint of trade and industry so we cao provide the competitive price and high quality product.
3.packing
we can do according to the customers' request.
4.transport
ems,dhl, tnt, ups ,fedex, by air, by sea
dhl express, fedex and ems for quantity less than 50kg, usually called as ddu service;
sea shipping for quantity over 500kg; and air shipping is available for 50kg above;
for high value products, please select air shipping and dhl express for safe;
5.service
we offer specialized logistic service including export declaration,customs clearance and every detail during shipment,this makes us able to offer you one-stop service from the order to the products transported to your hand.
we will try our best to satisfied you.
1. tailor-made for every customers.
2. third-party test for the products you demand.
3. test your counter-samples and produce them for you.
4. best discount for old customers.
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