CAS 599-79-1 Salicylazosulfapyridine / Sulfasalazine supplier in China
Details
Name | Salicylazosulfapyridine |
Synonyms | 2-Hydroxy-5-[[4-[(2-pyridinylamino)sulfonyl]phenyl]azo]benzoic acid; 5-(p-(2-pyridylsulfamoyl)phenylazo)salicylic acid;
Salazosulfapyridine; Sulfasalazine |
Brand | Salus |
Molecular Formula | C18H14N4O5S |
Molecular Weight | 398.39 |
CAS Registry Number | 599-79-1 |
EINECS | 209-974-3 |
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Sulfasalazine is an antiinflammatory agent that inhibits GSH-H-transferase. Sulfasalazine largely inhibits NF-κB activation and
induces apoptosis in T-lymphocytes. The compound also engages neutrophil apoptosis that can be abrogated by Tyr-K
inhibitors, PKA inhibitors, or antioxidants. Sulfasalazine is shown to inhibit basic fibroblast growth factor-induced endothelial
cell chemotaxis. Sulfasalazine is an inhibitor of TNFα and an activator of PPARγ.
China
