Isosorbide dinitrate dinitrate 40% NEW

$0.00 1KG

$0.00 25KG

Min. Order1KG
Purity38%～42%,EP10
Cas No87-33-2
Supply Ability100kg/month
Update time2025-12-26

Wuhan Fortuna Chemical Co., Ltd

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Chemical Properties

Product Name	Isosorbide dinitrate dinitrate 40%
CAS No	87-33-2
EC-No	201-740-9
Min. Order	1KG
Purity	38%～42%,EP10
Supply Ability	100kg/month
Release date	2025/12/26

Specification

Appearance	white powder
Impurity A	≤0.5%
Residual solvents	≤5000ppm
Assay	38%～42%

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Isosorbide dinitrate is a vasodilator medication primarily used to prevent and treat angina pectoris (chest pain caused by reduced blood flow to the heart).

Core Classification & Mechanism

It belongs to the nitrate class of drugs, a group known for relaxing blood vessels.
It works by converting to nitric oxide in the body, which dilates (widens) coronary arteries, improving blood flow to the heart muscle. It also dilates peripheral blood vessels, reducing the heart’s workload (preload and afterload) and oxygen demand.

Key Uses

Prevention of Angina: Long-acting formulations (tablets, capsules, patches) are used to reduce the frequency and severity of angina episodes in patients with coronary artery disease.
Acute Relief of Angina: Sublingual tablets or sprays act quickly (within minutes) to relieve sudden chest pain by rapidly dilating blood vessels.
Heart Failure Management: Sometimes used as an adjunct therapy in severe heart failure to improve blood flow and reduce symptoms like shortness of breath.

Important Safety & Usage Notes

Contraindications: Not for use in patients with hypersensitivity to nitrates, severe anemia, hypotension (low blood pressure), or those taking phosphodiesterase type 5 (PDE5) inhibitors (e.g., sildenafil, tadalafil)—this combination can cause life-threatening low blood pressure.
Common Side Effects: Headache (often temporary, most common with initial use), flushing of the face/neck, dizziness, and lightheadedness. These typically diminish with continued use.
Precautions: Avoid sudden position changes (e.g., standing up quickly) to prevent dizziness from low blood pressure. Use cautiously in patients with kidney or liver impairment, or a history of syncope (fainting).
Tolerance Risk: Prolonged continuous use can lead to nitrate tolerance (reduced effectiveness). To avoid this, healthcare providers may recommend a "nitrate-free interval" (e.g., 10–12 hours daily) with long-acting formulations.

Formulations & Dosing

Sublingual Tablets/Sprays: Fast-acting (1–3 minutes onset), used for acute angina relief.
Oral Tablets/Capsules (Immediate/Extended-Release): For long-term angina prevention, dosed 2–4 times daily (immediate-release) or once daily (extended-release).
Transdermal Patches: Applied once daily, provide continuous nitrate delivery for angina prevention.

Clinical Considerations

It is available by prescription only, requiring medical supervision to adjust dosage and monitor for side effects.
Patients should carry sublingual formulations at all times for emergency angina relief.
If chest pain persists despite use, or is accompanied by sweating, shortness of breath, or radiation to the jaw/arm, seek emergency medical care (may indicate a heart attack).

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