NAD+ is an important coenzyme of the tricarboxylic acid cycle, promoting the metabolism of sugars, fats and amino acids and participating in energy synthesis; NAD+ is also the only substrate for coenzyme I depleting enzymes (the only substrate for DNA repair enzyme PARP, the only substrate for long-lived proteins sirtuins, the only substrate of cyclic ADP ribose synthase CD38/157). It can improve eyesight, antioxidant, anti-aging and beauty care; it also can improve memory and prevent heart disease.