Primaquine diphosphate NEW

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Min. Order1KG
Purity98.5%
Cas No63-45-6
Supply Ability500kg/month
Update time2026-07-01

Wuhan Fortuna Chemical Co., Ltd

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Chemical Properties

Product Name	Primaquine diphosphate
CAS No	63-45-6
EC-No	200-560-8
Min. Order	1KG
Purity	98.5%
Supply Ability	500kg/month
Release date	2026/07/01

Specification

Items	Specifications	Results
Appearance	Orange-red crystalline powder	Complies
Identification	Complies	Complies
Acidity	2.5-3.5	2.9
Loss on drying	≤0.5%	0.04%
Related substances(HPLC)	Impurity A≤0.6% Impurity B≤2.0% Impurity C≤0.5% Any other single impurity≤0.2% Total impurities≤3.0%	0.22% 0.47% ND 0.01% 0.70%
Residual solvent	Methanol≤3000ppm Ethanol ≤5000ppm Toluene ≤890ppm	324ppm 4ppm 79ppm
Microbial Limits	Total Aerobic count≤1000CFU/g Moulds and yeasts ≤100CFU/g	＜10CFU/g ＜10CFU/g
Assay(On dried)	97.0%~102.0%	99.8%
Conclusion	The product conforms to the above specifications.

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Primaquine diphosphate is the phosphate salt form of primaquine, an antimalarial medication. It is commonly used in the treatment and prevention of certain types of malaria, particularly those caused by Plasmodium vivax and Plasmodium ovale. The diphosphate salt improves the drug’s stability and solubility for pharmaceutical use.

Chemical & Pharmaceutical Background

Active moiety: Primaquine
Salt form: Diphosphate (two phosphate groups)
Class: 8-aminoquinoline derivative
Administration: Oral (tablets)

Primary Medical Uses

1. Radical Cure of P. vivax and P. ovale Malaria

These malaria parasites can form dormant liver stages called hypnozoites, which can reactivate weeks or months after the initial infection, causing relapses.
Primaquine is the only widely available drug that eliminates these hypnozoites from the liver, providing a "radical cure" (complete eradication of the parasite).
It is typically given after a blood-stage treatment like chloroquine or artemisinin-based therapy.

2. Prevention of Relapse

A full course (usually 14 days) of primaquine diphosphate prevents future relapses in patients infected with P. vivax or P. ovale.

3. Transmission Blocking in P. falciparum Malaria

Primaquine can kill gametocytes (sexual forms of the malaria parasite) in P. falciparum, reducing transmission to mosquitoes.
A single low dose (0.25 mg/kg) is often added to artemisinin-based combination therapy (ACT) in public health programs to block spread, especially in elimination campaigns.

Important Considerations & Warnings

🔴 G6PD Deficiency Risk

Primaquine can cause severe hemolytic anemia in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency.
Testing for G6PD deficiency is mandatory before prescribing primaquine.
In G6PD-deficient patients, modified regimens (e.g., weekly dosing under supervision) may be used if benefits outweigh risks.

🚫 Contraindications

Known G6PD deficiency (unless managed carefully)
Pregnancy (primaquine may harm the fetus; alternative strategies used)
Severe rheumatoid arthritis or lupus (due to risk of oxidant stress)

💊 Dosage

For radical cure: 0.25–0.5 mg base/kg/day for 14 days (dose depends on region and resistance patterns).
Note: Dosing is based on the primaquine base, not the diphosphate salt—pharmaceutical labels specify equivalent base amounts.

Summary

Primaquine diphosphate is a crucial antimalarial drug used to:

Eradicate dormant liver stages of P. vivax and P. ovale (preventing relapse),
Block transmission of P. falciparum by killing gametocytes.

Its use requires careful screening for G6PD deficiency due to the risk of life-threatening hemolysis. Despite this, it remains essential for malaria elimination efforts worldwide.