Specification of Azelastine CAS 58581-89-8:
Items | Specifications | Results |
Appearance | White or almost white powder | White powder |
Loss on Drying | ≤1.0% | 0.46% |
Purity (HPLC) | ≥98.0% | 99.12% |
Conclusion | The product conforms to the above specifications. |
Welcome to inquire us to get the complete COA
Azelastine is a potent, second-generation antihistamine with additional anti-inflammatory properties. It is primarily used to treat allergic conditions affecting the eyes and nasal passages.
Chemical & Pharmacological Profile:
Class: Phthalazinone derivative
Mechanism: Blocks histamine H₁ receptors and inhibits the release of inflammatory mediators (e.g., leukotrienes, serotonin, platelet-activating factor).
Formulations: Available as nasal spray, ophthalmic (eye) drops, and occasionally oral tablets (less common).
Onset of Action: Rapid—within 15–30 minutes for nasal and ocular forms.
Main Medical Uses:
Allergic Rhinitis (Seasonal & Perennial)
Azelastine nasal spray reduces symptoms like sneezing, runny nose, itching, and congestion.
Allergic Conjunctivitis
Eye drops relieve redness, itching, and watering caused by allergens (e.g., pollen, dust).
Vasomotor Rhinitis (Non-allergic rhinitis)
Effective in reducing nasal symptoms not caused by allergies, thanks to its anti-inflammatory effects.
Adjunct in Asthma or Chronic Cough (Off-label, limited use)
Occasionally used when upper airway inflammation contributes to symptoms.
Advantages:
Dual action: antihistaminic + mast cell stabilizing
Local administration minimizes systemic side effects
Generally well-tolerated; common side effect is mild bitter taste (nasal spray) or transient stinging (eye drops)
Azelastine is valued for its fast relief and effectiveness in managing both allergic and non-allergic upper airway conditions.
Package of Azelastine CAS 58581-89-8:
Application of Azelastine CAS 58581-89-8:
Used for the treatment of bronchial asthma and nasal allergies.
China
