Pyrimethamine

Melting point  233-234°C 

Boiling point  393.35°C (rough estimate) 

density  1.2171 (rough estimate) 

refractive index  1.6110 (estimate) 

storage temp.  0-6°C 

solubility  Prepare the solution immediately before use. Dissolve 0.25 g in a mixture of 1 volume of methanol R and 3 volumes of methylene chloride R and dilute to 10 mL with the same mixture of solvents. The solution is clear (2.2.1) and not more intensely coloured than reference solution BY6 (2.2.2, Method II). 

form  neat 

pka pKa 7(t=20.0) (Uncertain) 

Water Solubility  <0.01 g/100 mL at 21 ºC