Product discription
Glycopyrrolate(Glycopyrronium Br) is a muscarinic competitive antagonist used as an antispasmodic.IC50 Value:Target: mAChR (Muscarinic acetylcholine receptor M1)in vitro: Glycopyrrolate showed no selectivity in its binding to the M1-M3 receptors. Kinetics studies, however, showed that glycopyrrolate dissociates slowly from HASM muscarinic receptors (60% protection against [3H]-NMS binding at 30 nM) compared to ipratropium bromide.in vivo: Glycopyrrolate (1 mg) tablets were then administered, starting with one tablet daily the third week and increasing the daily dose by one tablet per week until a maximum of four tablets during week six and 4 days of week seven when the daily dose was reduced to two tablets for 3 days. glycopyrrolate can be given in controlled doses provided that an adequate medical assessment has been undertaken. Glycopyrrolate has a slow and erratic absorption from the gastrointestinal system, but even low plasma levels are associated with a distinct and long-lasting antisialogic effect. Oral glycopyrrolate is emerging as a potential second-line treatment option, but experience with safety, efficacy, and dosing is especially limited in children. phase III study, 52.3% of glycopyrrolate oral solution recipients (aged 3-18 years; n = 137) had an mTDS response (primary endpoint); the response rate was consistently above 50% at all 4-weekly timepoints, aside from the first assessment at week 4 (40.3%). In general, glycopyrrolate oral solution was well tolerated in clinical trials. The majority of adverse events were within expectations as characteristic anticholinergic outcomes.Toxicity: Side effects include dry mouth, difficult urinating, heachaches, diarrhea and constipation. The medication also induces drowsiness or blurred vision. LD50=709 mg/kg (rat, oral).
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Company information
Hebei Lvyang Biotechnology Co.,Ltd.
is a specialized production enterprise integrating scientific research, production, processing and export.mainly deal in pharmaceutical intermediates,various industrial chemicals and Food Additives.Our products are widely used in Food & Beverage industry, Chemical industry, and Pharmacy industry,etc.
our products have spread over more than 30 countries in the world, the U.S.A, Poland, Canada, Italy, India,Brazil, Saudi Arabia, Israel, South Africa, Kenya, Latvia, U.K., Germany, Czech, Switzerland, Norway, Ethiopia, Chile, New Zealand, Australia, Columbia and so on.
We has established and improved the strict quality standard inspection system. In addition to the ISO9001 certification system, the company also commissioned SGS testing and testing institutions to test the quality of our products with national standards as the benchmark, we do our best to satisfy our customers with our quality.
We are a professional and experienced team and we promise clients to provide the best quality, price and service. Besides, in the business cooperation with clients, we still abide by principle of equality and mutual benefit, deeply trusted and recognized by clients.
Why choose us
1.Best service, high quality and reasonable price
2.It's customers' right to choose the package (EMS, DHL, FedEx, UPS);
3.It's customers' right to choose the packing way for his products from many recent effective packing ways.
4.Specials are possible when client's order is big enough, including the discount policy;
5.Our company promise to deliver clients' package to his hands safely, or we'll cover the total loss and reship in time;
6. Return policy: we promise we will return your money if our product don't have effect.
FAQ
1.Q: Can i get some samples?
A:Yes, we can supply the free sample ,but the shipping cost be paid by customer.
2.Q:How to start orders or make payment?
A:WesternUnion,bitcoin ,etc.
3.Q:How to confirm the Product Quality before placing orders?
A:We have complete QS system,and will provide the test report.You can get free samples for some products,you only need to pay the shipping cost.
4.Q:What's your MOQ?
A: Depending on the cost of product,it will be 5g if cost is high.
5.Q:How about delivery leadtime?
A:Within 2 working days after payment confirmed.
6.Q:How do you control the safety of your products ?
A:Control raw material to finished product, third party report
7.Q:Is it field inspection available ?
A:Yes,we support field inspection.
8.Q:How long does it take to the goods arrived?
A:For 1KG-100KG, Within 5-7 days by DHL,UPS,TNT, FEDEX,EMS Over 100KG.within 5-8days by air,20-40days by sea.
9.Q:How about Customs clearance?Will you refund or reship if it is seized?
A: We have full of experience to do the customs clearance,generally it will have no trouble.And we will reship or refund for you if it is seized by our mistake.
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