Introduction
Basic Info.
Model NO.
CAS 1454846-35-5
Packing
Foil Bag/Drum or According to Your Requirements
Specification
CAS 1454846-35-5
| Item Name | PF-06463922 |
| CAS NO | 1454846-35-5 |
| Molecular Formula | C21H19FN6O2 |
| Molecular Weight | 406.4129632 |
| Function | Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase that promotes cell proliferation and blocks apoptosis. PF-06463922 is an ATP-competitive, selective inhibitor of ALK (Ki = < 0.07 nM) and c-Ros oncogene 1 (ROS1, Ki = 0.7 nM).1 It has strong activity against all known ALK and ROS1 mutants identified in patients, including the EML4-L1196M mutant of ALK (Ki = < 0.02 nM).1,2,3 PF-06463922 is orally available, displaying inhibition of ALK phosphorylation and antitumor efficacy in a xenograft model expressing EML4-L1196M ALK.1,4 It demonstrates efficient blood-brain barrier penetration, produces brain tumor regression in mice harboring EML4-ALK tumors, and increases overall survival. |
| Apparence | White Powder |
| Package | Aluminum Bag;Drums;Paper Box Outside |
| Shipment | FedEx;DHL;UPS;TNT;EMS;Sea;Air. |
| Payment | Western Union;T/T;Trade Assurance;L/C |
| Warranty | 2 Years |
About Us
Our company is a hi-tech enterprise integrating R & D, production, agency and sales of fine chemicals such as inorganic chemicals, organic chemicals, flavors and fragrances, pharmaceutical raw materials and intermediates. We have established long-term cooperation with many large group companies at home and abroad.
FAQ:
Q1: Can i get some samples?
A: Yes, we can supply the sample, but the shipping cost be paid by our customers.
Q2: How to start orders or make payments?
A: Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T, Western Union or Paypal and so on.
Q3: How to confirm the Product Quality before placing orders?
A:You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.
Q4:What's your MOQ?
A:Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.
Q5: How about delivery lead time?
A:Delivery lead time: About 3-5 days after payment confirmed. (Chinese holiday not included)
China
