Product Description
1.Product Name: doxycycline hydrochloride
2.CAS NO: 10592-13-9
3.Application: Its antibacterial spectrum is very close to Tetracycline and Terramycin, but it has better effect, be sensitive to the Staphylococcus Aureus of tetracycline-resistant, oxytetracycline, long lasting time.
4.Sample: With Free
5.Specification:
Item | Standard |
Character | Yellow crystalline Powder |
Solubility | Freely soluble in water and in methanol, sparingly soluble in ethanol ( 96 per cent ). It dissolves in solutions of alkali hydroxides and carbonates. |
Identification | a) HPLC |
b) Sulphurie acid reaction a yellow colour develops |
c) It gives reaction of chlorides |
PH | 2.0-3.0 |
Specific Absorbance | At 349 nm E ( 1% ) 300-335 ( anhydrous and ethanol-free substance ) |
Specific Optical Rotation | -120°~-105° ( anhydrous and ethanol-free substance ) |
Heavy Metal | ≤50ppm |
Light-absorbing Impurities | At 490nm≤0.07 ( anhydrous and ethanol-free substance ) |
a) 6-epidoxycycline ≤2.0% |
b) metacycline ≤2.0% |
c) 4-epidoxycycline ≤ 0.5% |
d) 4-epi-6-epidoxycycline≤ 0.5% |
e) oxytetracycline≤ 0.5% |
f) 2-acety-2-decarbamoyldoxycycline ADOT ≤ 0.5% |
g) any other impurity≤ 0.5% |
Ethanol | 4.3-6.0% ( m/m ) |
Sulphated Ash | ≤ 0.4% |
Water | 1.4-2.8% |
Assay | 95.0%-102.0% ( C22H25CIN2O8 ) ( anhydrous and ethanol-free substance ) |
Conclusion: This product fulfills EP7.4, BP2010. |
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