Basic Information
Other name: 2,2'-(1,2-Ethanediyldiimino)bis-1-butanol dihydrochloride;[S-(R*,R*)]-2,2'-(Ethylenediimino)dibutan-1-ol dihydrochloride
CAS NO.: 1070-11-7
EINECS NO.: 213-970-7
MF: C10H26Cl2N2O2
MW: 277.23
InChI: 1S/C10H24N2O2.2ClH/c1-3-9(7-13)11-5-6-12-10(4-2)8-14;;/h9-14H,3-8H2,1-2H3;2*1H
Melting point: 198-200ºC
Boiling point: 376.2°C at 760 mmHg
Flash point: 181.3°C
Appearance: white crystalline powder
Standard: USP/CP/BP/EP
Function
1. Pharmacologically, this product is a synthetic bacteriostatic anti-tuberculosis drug. It has strong activity against bacteria in the growth and reproduction period, and has little effect on bacteria in stationary phase. It has high antibacterial activity against various types of mycobacteria. Mycobacterium tuberculosis has no cross-resistance between this product and other drugs. The mechanism of action of this product has not been fully elucidated, which may inhibit the metabolism of sensitive bacteria, inhibit the synthesis of RNA, interfere with the protein metabolism of Mycobacterium tuberculosis, and cause bacterial death.
2. Toxicology This product can cause cleft palate, brain exposure and spinal deformity in mice in large doses; it can cause mild cervical deformity in rat test; it can cause one eye, short limb and cleft palate in rabbit test.
3. Combined with rifampicin or isoniazid to treat various types of active tuberculosis. Can also be used for the treatment of atypical M. tuberculosis infection
COA
China
