Melting point 207-208 °C(lit.)
alpha -37 º (c=1, CHCl3)
Boiling point 504.87°C (rough estimate)
density 1.1061 (rough estimate)
refractive index -36 ° (C=1, CHCl3)
storage temp. Store at RT
solubility Practically insoluble in water, soluble in ethanol (96 per cent).
form Powder
color White to yellow-white
Uses Spironolactone, an aldosterone-, and competitive androgen-receptor-antagonist and 5-alpharductase- inhibitor, indicated for the treatment of androgen dependent hirsutism, ideally in doses of 50 to 200 mg per day accompanying the intake of oral contraceptives with the same seven day break in between. Side effects concerning the length of the menstrual cycle, the increase of blood pressure or potassium levels may occur. Spironolactone is the number one drug in the treatment of hirsutism in the US (Farquhar et al., 2003). In other countries the prescription of spironolactone for the treatment of hirsutism may be off-label.
Uses It is a synthetic 17-lactone steroid which is a renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics, used primarily to treat ascites in patients with liver disease, low-renin hypertension, hypokalemia
Uses diuretic, aldosterone antagonist
China
