Spironolactone

$0.00 1kg

$0.00 25kg

$0.00 50kg

Min. Order1kg
Purity99%
Cas No52-01-7
Supply Ability50tons
Update time2023-09-14

Wuhan Han Sheng New Material Technology Co.，Ltd

2YR

China

Chemical Properties

Product Name	Spironolactone
CAS No	52-01-7
EC-No	200-133-6
Min. Order	1kg
Purity	99%
Supply Ability	50tons
Release date	2023/09/14

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CAS No.: 52-01-7
Chemical Name: Spironolactone
Molecular Formula: C24H32O4S
Molecular Weight: 416.58
EINECS: 200-133-6

Melting point	207-208 °C (lit.)
alpha	-37 º (c=1, CHCl3)
Boiling point	504.87°C (rough estimate)
Density	1.1061 (rough estimate)
refractive index	-36 ° (C=1, CHCl3)
storage temp.	2-8°C
solubility	Practically insoluble in water, soluble in ethanol (96 per cent).
form	Powder
color	White to yellow-white
Water Solubility	practically insoluble
Merck	14,8760
BCS Class	2,4,3
LogP	2.780

Definition

A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.

Uses

It can be used as a kind of inefficient diuretic drugs.
It is a synthetic 17-lactone steroid which is a kind of renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics, used primarily to treat ascites in patients with liver disease, low-renin hypertension and hypokalemia.
The active metabolite of lactone (spironolactone); It can be used for the Inhibition of aldosterone biosynthesis. It can also be used as the blocker of the Quabain effect.

Spironolactone, an aldosterone-, and competitive androgen-receptor-antagonist and 5-alpharductase- inhibitor, indicated for the treatment of androgen dependent hirsutism, ideally in doses of 50 to 200 mg per day accompanying the intake of oral contraceptives with the same seven day break in between. Side effects concerning the length of the menstrual cycle, the increase of blood pressure or potassium levels may occur. Spironolactone is the number one drug in the treatment of hirsutism in the US (Farquhar et al., 2003). In other countries the prescription of spironolactone for the treatment of hirsutism may be off-label.

It is a synthetic 17-lactone steroid which is a renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics, used primarily to treat ascites in patients with liver disease, low-renin hypertension, hypokalemia

diuretic, aldosterone antagonist