| 名称 | 11-Beta-hydroxyandrostenedione |
| 描述 | 11-Beta-hydroxyandrostenedione (NSC-17102) is a steroid mainly found in the adrenal origin (11β-hydroxylase is present in adrenal tissue, but absent in ovarian tissue), which is a 11β-hydroxysteroid dehydrogenase isozymes inhibitor. Measuring plasma 11-Beta-hydroxyandrostenedione can distinguish the adrenal or ovarian origin of hyperandrogenism with 4-androstenedione increases. |
| 体外活性 | 21-deoxycortisol (21dF) and 21-deoxycortisone (21dE) are assayed within the LNCaP cell line to establish that this conversion is catalyzed by the lyase activity of CYP17A1. After the transfection of CYP17A1, 11-Beta-hydroxyandrostenedione (11OHA4)-pathway metabolites increase, 21dF, and 21dE are in fact metabolized to 11-Beta-hydroxyandrostenedione and 11-ketoprogesterone (11KP4) by CYP17A1, respectively [2]. |
| 体内活性 | In 21-hydroxylase deficiency, Cushing's syndrome, and hyperandrogenism of adrenal origin, the plasma concentration of 11-Beta-hydroxyandrostenedione (11beta-hydroxy-4-androstene-3,17-dione) is very high. In congenital 11-hydroxylase deficiency and adrenal insufficiency, the plasma concentration of 11-Beta-hydroxyandrostenedione (11beta-hydroxy-4-androstene-3,17-dione) is very low. Thus, when plasma 4-androstenedione is elevated, it is useful to measure the plasma 11-Beta-hydroxyandrostenedione level in order to determine the adrenal or ovarian origin of the hyperandrogenism [1]. |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 45 mg/mL (148.8 mM), Sonication is recommended.
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| 关键字 | 11Betahydroxyandrostenedione | inhibit | 4-androstenedione | Cushing's | hyperandrogenism | adrenal | syndrome | Inhibitor | NSC17102 | 4-Androsten-11b-ol-3,17-dione | Endogenous Metabolite | 4-Androsten-11beta-ol-3,17-dione | NSC 17102 | steroid | 11-Beta-hydroxyandrostenedione | 11-β-hydroxyandrostenedione | 11 Beta hydroxyandrostenedione | 11-b-hydroxyandrostenedione | 11β-hydroxylase | ovarian |
| 相关产品 | Sucrose | Daidzein | Guanidine hydrochloride | Fumaric acid | Ferulic Acid | Vanillin | Formamide | Glycerol | Thymidine | Naringin | 3-Indoleacetic acid | Oleic acid |
| 相关库 | 经典已知活性库 | ReFRAME 相关化合物库 | 天然产物库 | 抑制剂库 | NO PAINS 化合物库 | 高通量筛选天然产物库 | Ro5类药天然产物库 | 人内源代谢化合物库 | 已知活性化合物库 | 小鼠代谢化合物库 |
United States
