Name | 3-O-Acetyl-11-hydroxy-beta-boswellic acid |
Description | 3-O-Acetyl-11-hydroxy-beta-boswellic acid, the precursor of 3-O-acetyl-9,11-dehydro-beta-boswellic acid (a 5-lipoxygenase inhibitor), |
In vitro | 4 pentacyclic triterpenoid acids were isolated from Boswellia carterii and identified by NMR and Mass spectroscopic analysis (compounds 1, 3-O-acetyl-9,11-dehydro-β-boswellic acid; 2, 3-O-Acetyl-11-hydroxy-beta-boswellic acid ; 3. 3-O- acetyl-11-keto-β-boswellic acid and 4, 11-keto-β-boswellic acid. Their inhibitory activity on Jack bean urease were evaluated. Docking and pharmacophore analysis using AutoDock 4.2 and Ligandscout 3.03 programs were also performed to explain possible mechanism of interaction between isolated compounds and urease enzyme. It was found that compound 1 has the strongest inhibitory activity against Jack bean urease (IC50 = 6.27 ± 0.03 μM), compared with thiourea as a standard inhibitor (IC50 = 21.1 ± 0.3 μM)[1] |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO : 50 mg/mL (97.14 mM)
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Keywords | Lipoxygenase | 3OAcetyl11hydroxybetaboswellic acid | LOX | Inhibitor | 3-O-Acetyl-11-hydroxy-b-boswellic acid | 3-O-Acetyl-11-hydroxy-β-boswellic acid | 3 O Acetyl 11 hydroxy beta boswellic acid | 3-O-Acetyl-11-hydroxy-beta-boswellic acid | inhibit |
Inhibitors Related | 2,5-Di-tert-butylhydroquinone | Caffeic Acid | 5-LOX inhibitor | Diethylcarbamazine citrate | Setileuton | Phenidone | Abietic Acid | Resveratrol | NNK | PF-4191834 | 5-Aminosalicylic Acid | Malotilate |
Related Compound Libraries | Terpene Natural Product Library | Traditional Chinese Medicine Monomer Library | Bioactive Compound Library | Rare Natural Product Library | Selected Plant-Sourced Compound Library | Inhibitor Library | Natural Product Library for HTS | Bioactive Compounds Library Max | Ancient Chinese Classical Formulas Compound Library |