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Isatin NEW
- Min. Order1kg
- Purity99%
- Cas No91-56-5
- Supply Abilityg-kg-tons, free sample is available
- Update time2024-03-29
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Product Name | Isatin |
CAS No | 91-56-5 |
EC-No | |
Min. Order | 1kg |
Purity | 99% |
Supply Ability | g-kg-tons, free sample is available |
Release date | 2024/03/29 |
1. Product information
Names
Name | isatin |
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Synonym | More Synonyms |
isatin Biological Activity
Description | Isatin (Indoline-2,3-dione) is a potent inhibitor of monoamine oxidase (MAO) with an IC50 of 3 μM. Also binds to central benzodiazepine receptors (IC50 against clonazepam, 123 μM)[1]. Also acts as an antagonist of both atrial natriuretic peptide stimulated and nitric oxide-stimulated guanylate cyclase activity[2]. Shows effect on the serotonergic system[3]. |
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Related Catalog | Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase Natural Products >> Alkaloid Research Areas >> Cancer Research Areas >> Cardiovascular Disease Research Areas >> Neurological Disease |
Target | IC50: 3 μM (MAO B)[1] |
In Vitro | In dopaminergic SH-SY5Y cells isatin (1-400 μM) induces cell death in dose- and time dependent manner. This death occurred as a continuum of survival, apoptosis and necrosis[2]. |
In Vivo | A single dose of isatin (80 mg/kg) has a rapid effect on the serotonergic system in the hypothalamus. Isatin significantly increases 5-HT concentrations in the hypothalamus and cortex but did not significantly alter 5-HIAA concentrations[3]. |
References | [1]. Glover V, et al. Isatin: Identity with the Purified Endogenous Monoamine Oxidase Inhibitor Tribulin. Journal of Neurochemistry, 51(2), 656–659. [2]. Igosheva N, et al. Isatin, an endogenous monoamine oxidase inhibitor, triggers a dose- and time-dependent switch from apoptosis to necrosis in human neuroblastoma cells. Neurochem Int. 2005 Aug;47(3):216-24. [3]. McIntyre IM, et al. Serotonergic effects of isatin: an endogenous MAO inhibitor related to tribulin. J Neural Transm Gen Sect. 1990;79(1-2):35-40. |
Chemical & Physical Properties
Density | 1.4±0.1 g/cm3 |
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Boiling Point | 360.3±52.0 °C at 760 mmHg |
Melting Point | 193-195 °C (dec.)(lit.) |
Molecular Formula | C8H5NO2 |
Molecular Weight | 147.131 |
Flash Point | 171.7±30.7 °C |
Exact Mass | 147.032028 |
PSA | 46.17000 |
LogP | -0.17 |
Vapour Pressure | 0.0±1.8 mmHg at 25°C |
Index of Refraction | 1.679 |
Storage condition | Store at RT. |
MSDS
isatin MSDS(Chinese) |
Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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Safety Information
Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
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Hazard Codes | Xi,Xn |
Risk Phrases | R36/37/38 |
Safety Phrases | S26-S36-S24/25 |
RIDADR | 2811 |
WGK Germany | 1 |
RTECS | NL7873000 |
Packaging Group | III |
Hazard Class | 6.1(b) |
HS Code | 2933990090 |
Synthetic Route
Previous 1/54 Next![]() Chloral hydrate 302-17-0 ![]() 74497-02-2 ~64% ![]() isatin 91-56-5 |
Literature: Liu, Hua-Quan; Wang, De-Cai; Wu, Fei; Tang, Wei; Ouyang, Ping-Kai Chinese Chemical Letters, 2013 , vol. 24, # 10 p. 929 - 933 |
![]() Indole 120-72-9 ~8% ![]() Oxindole 59-48-3 ![]() isatin 91-56-5 |
Literature: Applied Catalysis A: General, , vol. 470, p. 427 - 433 |
![]() Indole 120-72-9 ~6% ![]() Oxindole 59-48-3 ![]() Indirubin 479-41-4 ![]() isatin 91-56-5 |
Literature: Applied Catalysis A: General, , vol. 470, p. 427 - 433 |
Precursor & DownStream
Precursor 9 | Previous 1/3 Next |
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DownStream 10 | Previous 1/3 Next |
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Customs
HS Code | 2933990090 |
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Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Articles78
More ArticlesUnprecedented one-pot, domino tertiary alcohol protection-Michael type addition of halides to Morita-Baylis-Hillman adduct of isatin with RCOX/K2CO3: diastereoselective synthesis of oxindole appended β-halo esters. Org. Lett. 15(6) , 1186-9, (2013) A facile method utilizing RCOX/K2CO3 as a novel reagent for conjugate addition of hydrogen halide, in addition to tertiary (3°)-hydroxyl protection that leads to the synthesis of functionalized β-halo... | |
Tryptophan 2,3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulators. J. Med. Chem. 54 , 5320, (2011) Tryptophan catabolism mediated by indoleamine 2,3-dioxygenase (IDO) is an important mechanism of peripheral immune tolerance contributing to tumoral immune resistance. IDO inhibition is thus an active... | |
Reactivity of dinuclear copper(II) complexes towards melanoma cells: Correlation with its stability, tyrosinase mimicking and nuclease activity. J. Inorg. Biochem. 149 , 49-58, (2015) In this work, the influence of two new dinuclear copper(II) complexes in the viability of melanoma cells (B16F10 and TM1MNG3) was investigated, with the aim of verifying possible correlations between ... |
Synonyms
Indolequinone |
EINECS 202-077-8 |
MFCD00005718 |
indole-2,3-dione |
indoline-2,3-dione |
Indoquinone |
2,3-Dioxoindoline |
2,3-Dioxo-2,3-dihydroindole |
2,3-Indolinedione |
2,3-INDOLEDIONE |
2H-Indol-2-one, 3-hydroxy- |
3-hydroxy-2-oxoindole |
ISATIC ANHYDRIDE |
Isotin |
2,3-Diketoindoline |
2-methopropan-1-ol |
3-Hydroxy-2H-indol-2-one |
Isatin |
2,3-KETOINDOLINE |
5-21-10-00221 (Beilstein Handbook Reference) |
2,3-dihydro-1H-indol-2,3-dione |
2. Packaging
For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.
For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product.
Or smaller package 1kg/bottle, 10kgs/bottle as request.
3. Shipping
4. Contact information
For more details, pls contact us freely.
Email address : Sun@fdachem.com
Mob: 86 13526505137
WhatsApp/Skype/Wechat/LINE: 86 13526505137
Company Profile Introduction
Henan Fengda Chemical Co., Ltd. is located in the High-tech Development Zone of Henan Province. Specializing in the production and sales of various fine chemical products required for industrial production, including chemical raw materials, organic raw materials, petrochemicals, chemical reagents, solvents, catalysts, and additives, etc.