Sodium dichloroacetate NEW

• MOLECULAR FORMULA :

• C2-H-Cl2-O2.Na

• MOLECULAR WEIGHT :

• 150.92

• WISWESSER LINE NOTATION :

• QVYGG &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - rat

• DOSE/DURATION :

• 5281 mg/kg

• TOXIC EFFECTS :

• Details of toxic effects not reported other than lethal dose value

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - mouse

• DOSE/DURATION :

• 4845 mg/kg

• TOXIC EFFECTS :

• Details of toxic effects not reported other than lethal dose value

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Intraperitoneal

• SPECIES OBSERVED :

• Rodent - mouse

• DOSE/DURATION :

• >3 gm/kg

• TOXIC EFFECTS :

• Details of toxic effects not reported other than lethal dose value

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - rat

• DOSE/DURATION :

• 30425 mg/kg/12W-C

• TOXIC EFFECTS :

• Brain and Coverings - changes in brain weight Endocrine - changes in adrenal weight Kidney, Ureter, Bladder - changes in bladder weight

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - rat

• DOSE/DURATION :

• 45500 mg/kg/13W-I

• TOXIC EFFECTS :

• Endocrine - hypoglycemia Liver - changes in liver weight Blood - changes in erythrocyte (RBC) count

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - rat

• DOSE/DURATION :

• 2450 mg/kg/7W-C

• TOXIC EFFECTS :

• Kidney, Ureter, Bladder - other changes in urine composition Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - mouse

• DOSE/DURATION :

• 61 gm/kg/12W-C

• TOXIC EFFECTS :

• Peripheral Nerve and Sensation - recording from peripheral motor nerve Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - changes in testicular weight

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Mammal - dog

• DOSE/DURATION :

• 4550 mg/kg/13W-I

• TOXIC EFFECTS :

• Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - food intake (animal) Blood - changes in erythrocyte (RBC) count

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - mouse

• DOSE/DURATION :

• 164 gm/kg/1Y-C

• TOXIC EFFECTS :

• Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• DOSE :

• 182 gm/kg

• SEX/DURATION :

• male 13 week(s) pre-mating

• TOXIC EFFECTS :

• Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• DOSE :

• 4375 mg/kg

• SEX/DURATION :

• male 10 week(s) pre-mating

• TOXIC EFFECTS :

• Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• DOSE :

• 2188 mg/kg

• SEX/DURATION :

• male 10 week(s) pre-mating

• TOXIC EFFECTS :

• Reproductive - Paternal Effects - testes, epididymis, sperm duct

MUTATION DATA

• TYPE OF TEST :

• Mutation in microorganisms

• TEST SYSTEM :

• Bacteria - Salmonella typhimurium

• DOSE/DURATION :

• 5 ug/plate

• REFERENCE :

• AJCNAC American Journal of Clinical Nutrition. (American Soc. for Clinical Nutrition, Inc., 9650 Rockville Pike, Bethesda, MD 20814) V.2- 1954- Volume(issue)/page/year: 33,1179,1980