Benzoic acid, 4-methyl-3-(tetrahydro-2,4-dioxo-1(2H)-pyrimidinyl)-

tDHU, acid is a dihydropyrimidinecereblon ligand that contains an E3 ligase ligand and a benzoic acid linker. tDHU, acid can be used as an E3 ubiquitin ligase ligand-Linker conjugate for the development of PROTACs[1].

tDHU, acid is a functionalized cereblon ligand for PROTAC research and development; incorporates an E3 ligase ligand plus a benzoic acid functional handle for ready conjugation to a linker/target protein ligand.

Cereblon

Store at -20°C

[1] Novartis AG, et al. Preparation of dihydropyrimidine derivatives as bifunctional degraders for the treatment and prophylaxis of target protein-mediated diseases. World Intellectual Property Organization, WO2021053495 A1 2021-03-25.