[[[(1S)-1-(4-BROMOPHENYL)ETHYL]AMINO](1,2,3,4-TETRAHYDRO-2,3-DIOXO-5-QUINOXALINYL)METHYL] PHOSPHONIC ACID TETRASODIUM HYDRATE
[[[(1S)-1-(4-BROMOPHENYL)ETHYL]AMINO](1,2,3,4-TETRAHYDRO-2,3-DIOXO-5-QUINOXALINYL)METHYL] PHOSPHONIC ACID TETRASODIUM HYDRATE
英文名称:PEAQX TETRASODIUM HYDRATE
CAS号:459836-30-7
分子式:C34H32Br2N6Na4O11P2
分子量:1014.366082
EINECS号:
Mol文件:Mol File
![[[[(1S)-1-(4-BROMOPHENYL)ETHYL]AMINO](1,2,3,4-TETRAHYDRO-2,3-DIOXO-5-QUINOXALINYL)METHYL] PHOSPHONIC ACID TETRASODIUM HYDRATE 结构式](https://img.chemicalbook.com/StructureFile/ChemBookStructure20/GIF/CB9830493.gif)
[[[(1S)-1-(4-BROMOPHENYL)ETHYL]AMINO](1,2,3,4-TETRAHYDRO-2,3-DIOXO-5-QUINOXALINYL)METHYL] PHOSPHONIC ACID TETRASODIUM HYDRATE 性质
| 密度 | 1.639±0.06 g/cm3(Predicted) |
|---|---|
| 储存条件 | -20°C |
| 形态 | 固体 |
| 酸度系数(pKa) | 1.19±0.10(Predicted) |
| 颜色 | 浅黄至卡其色 |
[[[(1S)-1-(4-BROMOPHENYL)ETHYL]AMINO](1,2,3,4-TETRAHYDRO-2,3-DIOXO-5-QUINOXALINYL)METHYL] PHOSPHONIC ACID TETRASODIUM HYDRATE 用途与合成方法
PEAQX (NVP-AAM077) tetrasodium hydrate 是有效的、选择性的、口服有效的 NMDA 拮抗剂，其对 hNMDAR 1A 和 hNMDAR 2A 的 IC50 值分别为 270 nM 和 29600 nM。
PEAQX (3 µM) produces similar caspase-3 activation, while NVP-AAM007 is approximately three-fold more potent.
PEAQX (10-40 mg/kg) dose-dependently increased cortical caspase-3 activity following sub-chronic administration.
PEAQX (10 and 20 mg/kg) shows enhanced locomotor activity in response to PCP challenge (4 mg/kg on PN28-35) compared to saline pretreatment (F
3, 73
=4.99).
PEAQX (10 mg/kg, ip) antagonizes the effects of PRE084 on CaMKIV-TORC1-CREB and BDNF, even for learning and memory impairment.
| Animal Model: | Timed, day 14 pregnant female Sprague-Dawley rats. |
| Dosage: | 10, 20 or 40 mg/kg. |
| Administration: | S.C. |
| Result: | Showed a sensitized locomotor response to PCP challenge on PN28-35. |
| Animal Model: | Timed, day 14 pregnant female Sprague-Dawley rats. |
| Dosage: | 4 mg/kg. |
| Administration: | I.P. |
| Result: | Did not significantly increase locomotor activity in rats treated sub-chronically with PEAQX on PN7, 9 and 11. |
| Animal Model: | 11-week old C57BL/6 mice. |
| Dosage: | 10 mg/kg. |
| Administration: | IP. |
| Result: | Reversed the effect of PRE084 (F 3,78 = 10.446, p<0.01). |
[[[(1S)-1-(4-BROMOPHENYL)ETHYL]AMINO](1,2,3,4-TETRAHYDRO-2,3-DIOXO-5-QUINOXALINYL)METHYL] PHOSPHONIC ACID TETRASODIUM HYDRATE 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-11-08 | HY-12294A | 1 mg | 545 | ||
| 2024-11-08 | HY-12294A | [[[(1S)-1-(4-BROMOPHENYL)ETHYL]AMINO](1,2,3,4-TETRAHYDRO-2,3-DIOXO-5-QUINOXALINYL)METHYL] PHOSPHONIC ACID TETRASODIUM HYDRATE | 459836-30-7 | 5mg | 1200 |
[[[(1S)-1-(4-BROMOPHENYL)ETHYL]AMINO](1,2,3,4-TETRAHYDRO-2,3-DIOXO-5-QUINOXALINYL)METHYL] PHOSPHONIC ACID TETRASODIUM HYDRATE供应商 更多
Sigma-Aldrich西格玛奥德里奇(上海)贸易有限公司
联系电话：021-61415566 800-8193336
产品介绍：
英文名称：PEAQX tetrasodium hydrate
CAS：459836-30-7
纯度：>=98% (HPLC)
包装信息：25MG
备注：P1999-25MG
天津普西唐生物医药科技有限公司
联系电话：010-60605840 15801484223;
产品介绍：
英文名称：PEAQX tetrasodium hydrate
纯度：98%
包装信息：5mg;10mg;50mg
最新发布供应信息
PEAQX四钠水合物|T16451|TargetMol
TargetMol中国（陶术生物）
2024-09-30
PEAQX 四钠 水合物,459836-30-7
西格玛奥德里奇（上海）贸易有限公司
2023-10-27
