Y-27632
Y-27632 性质
| 熔点 | >260°C (dec.) |
|---|---|
| 沸点 | 462.6±15.0 °C(Predicted) |
| 密度 | 1.136±0.06 g/cm3(Predicted) |
| 储存条件 | Keep in dark place,Sealed in dry,2-8°C |
| 溶解度 | H2O: 14 mg/mL |
| 酸度系数(pKa) | 13.53±0.40(Predicted) |
| 形态 | 固体 |
| 颜色 | 白色 |
| 稳定性 | 吸湿性 |
| InChI | InChI=1S/C14H21N3O/c1-10(15)11-2-4-12(5-3-11)14(18)17-13-6-8-16-9-7-13/h6-12H,2-5,15H2,1H3,(H,16,17,18)/t10-,11-,12-/m1/s1 |
| InChIKey | IYOZTVGMEWJPKR-IJLUTSLNSA-N |
| SMILES | [C@@H]1(C(NC2C=CN=CC=2)=O)CC[C@@H]([C@H](N)C)CC1 |
Y-27632 用途与合成方法
|
ROCK-I 220 nM (Ki) |
ROCK-II 300 nM (Ki) |
PKN 3.1 μM (Ki) |
Citron kinase 5.3 μM (Ki) |
PKCα 73 μM (Ki) |
PKA 25 μM (Ki) |
Y-27632 inhibits the ROCK family of kinases 100 times more potently than other kinases including protein kinase C, cAMP-dependent kinase and myosin light chain kinase. Y-27632 prolongs the lag time and delays the appearance of BrdU-labeled cells in a concentration-dependent manner, delays of about 1 and 4 h are noticed in the Swiss 3T3 cells treated with 10 and 100 μM Y-27632, respectively. Y-27632 promotes neuronal differentiation of adipose tissue-derived stem cells (ADSCs). Compared to 1.0 and 2.5 μM Y-27632 induced groups, percentages of neuroal-like cells achieved a peak in the 5.0 μM Y-27632 induced group.
Y-27632 (5 and 10 mg/kg) significantly prolongs the onset time of myoclonic jerks when compare with saline group. Y-27632 (5 and 10 mg/kg) significantly prolongs the onset time of clonic convulsions when compare with saline group. Treatment with Dimethylnitrosamine (DMN) causes a significant decrease in rat body and liver weight (DMN-S group) compared with control animals (S-S group). Oral Y27632 (30 mg/kg) essentially prevents this DMN-induced rat body and liver weight loss (DMN-Y group).
Y-27632 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026-06-05 | HY-10071 | Y-27632二盐酸盐 | 146986-50-7 | 1 mg | 300 |
| 2026-06-05 | HY-10071 | Y-27632二盐酸盐 | 146986-50-7 | 5mg | 700 |
