AC-FLTD-CMK
![AC-FLTD-CMK 结构式](https://img.chemicalbook.com/CAS/20211123/GIF/2376255-48-8.gif)
AC-FLTD-CMK 性质
沸点 | 962.7±65.0 °C(Predicted) |
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密度 | 1.275±0.06 g/cm3(Predicted) |
储存条件 | Store at -20°C, protect from light, stored under nitrogen |
溶解度 | 在 DMSO 中的溶解度为 1 mg/ml |
酸度系数(pKa) | 3.93±0.19(Predicted) |
AC-FLTD-CMK 用途与合成方法
Caspase-1 46.7 nM (IC 50 ) |
Caspase-4 1.49 μM (IC 50 ) |
Caspase-5 329 nM (IC 50 ) |
Caspase-11
|
Ac-FLTD-CMK, inhibits GSDMD cleavage by caspases-1, -4, -5, and -11 in vitro, suppresses pyroptosis downstream of both canonical and noncanonical inflammasomes, as well as reduces IL-1β release following activation of the NLRP3 inflammasome in macrophages. By contrast, Ac-FLTD-CMK does not target caspase-3 or apoptotic cell death. Crystal structure of caspase-1 in complex with Ac-FLTD-CMK reveals extensive enzyme-inhibitor interactions involving both hydrogen bonds and hydrophobic contacts.