AC-FLTD-CMK
AC-FLTD-CMK 性质
| 沸点 | 962.7±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.275±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C, protect from light, stored under nitrogen |
| 溶解度 | 在 DMSO 中的溶解度为 1 mg/ml |
| 酸度系数(pKa) | 3.93±0.19(Predicted) |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
| InChIKey | UCWNTWGHVCSMJP-AIPSELJTNA-N |
| SMILES | [C@@H](CC(C)C)(NC(=O)[C@@H](NC(=O)C)CC1C=CC=CC=1)C(=O)N[C@@H]([C@H](O)C)C(=O)N[C@@H](CC(=O)O)C(=O)CCl |&1:0,8,23,24,30,r| |
AC-FLTD-CMK 用途与合成方法
|
Caspase-1 46.7 nM (IC 50 ) |
Caspase-4 1.49 μM (IC 50 ) |
Caspase-5 329 nM (IC 50 ) |
Caspase-11
|
Ac-FLTD-CMK, inhibits GSDMD cleavage by caspases-1, -4, -5, and -11 in vitro, suppresses pyroptosis downstream of both canonical and noncanonical inflammasomes, as well as reduces IL-1β release following activation of the NLRP3 inflammasome in macrophages. By contrast, Ac-FLTD-CMK does not target caspase-3 or apoptotic cell death. Crystal structure of caspase-1 in complex with Ac-FLTD-CMK reveals extensive enzyme-inhibitor interactions involving both hydrogen bonds and hydrophobic contacts.
AC-FLTD-CMK 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026-09-15 | HY-111675 | AC-FLTD-CMK | 2376255-48-8 | 1 mg | 3700 |
| 2026-09-15 | HY-111675 | AC-FLTD-CMK | 2376255-48-8 | 10 mM * 1 mL in DMSO | 10564 |
