1-Benzyloxycarbonylamino-2-propanone (3) (8.6 g, 42 mmol) was used as a raw material, which was dissolved in ethanol (50 mL) and 1N hydrochloric acid solution (46 mL) was added. The reaction was stirred in the presence of Pd/C catalyst (1.5 g, 10%) for 4 h at room temperature in a hydrogen atmosphere (1 atm). Upon completion of the reaction, the reaction mixture was filtered to remove the catalyst and the filtrate was concentrated. The resulting residue was ground with ether (Et2O) to give 1-amino-2-propanone hydrochloride (4.6 g, 100%) as a white solid.1H NMR (CD3OD) data: δ 3.92 (s, 2H), 2.12 (s, 3H).
