H-Arg-Gly-Asp-Cys-OH trifluoroacetate salt

H-Arg-Gly-Asp-Cys-OH is a tetrapeptide that contains the arginine-glycine-aspartate (RGD) motif, a sequence that acts as a recognition site for various adhesion proteins.1 It inhibits the binding of fibrinogen to endothelial cells and ADP-stimulated platelets with IC50 values of 320 and 35 µM, respectively.2 Implantation of titanium rods coated with H-Arg-Gly-Asp-Cys-OH increases bone formation in rat femurs.3 H-Arg-Gly-Asp-Cys-OH has been conjugated to polyethylenimine to improve gene transfection efficiency.4WARNING This product is not for human or veterinary use.

[1] HAE SOOK PARK  Young K K  Choonmi Kim. Preferred conformations of RGDX tetrapeptides to inhibit the binding of fibrinogen to platelets[J]. Biopolymers, 2002, 63 5: 298-313. DOI: 10.1002/bip.10067
[2] L TRANQUI. Differential structural requirements for fibrinogen binding to platelets and to endothelial cells.[J]. Journal of Cell Biology, 1989, 108 6: 2519-2527. DOI: 10.1083/jcb.108.6.2519
[3] D M FERRIS. RGD-coated titanium implants stimulate increased bone formation in vivo.[J]. Biomaterials, 1999, 20 23-24: 2323-2331. DOI: 10.1016/s0142-9612(99)00161-1
[4] KLAUS KUNATH. Integrin targeting using RGD-PEI conjugates for in vitro gene transfer[J]. Journal of Gene Medicine, 2003, 5 7: 588-599. DOI: 10.1002/jgm.382