20-CARBOXY-LEUKOTRIENE B4

20-carboxy LTB₄ is a metabolite of LTB₄ in human neutrophils. In human leukocytes, LTB₄ is inactivated by the enzyme LTB₄ 20-hydroxylase. The resulting 20-hydroxy LTB₄ is further oxidized to 20-carboxy LTB₄. LTB₄ metabolism in isolated rat hepatocytes also results in production of 20-carboxy LTB₄ along with other ω-oxidation products. The biological activity of 20-carboxy LTB₄ is only about 2.6% compared to that of LTB₄ in causing PMNL degranulation.

20-COOH-LTB4 is a leukotriene B4 metabolite and substrate for β-oxidation pathways.

ChEBI: A member of the class of leukotrienes that is leukotriene B4 in which the terminal methyl group has undergone formal oxidation to the corresponding carboxylic acid.

Human Endogenous Metabolite; BLT1

[1] G?RAN HANSSON . Identification and biological activity of novel ω-oxidized metabolites of leukotriene B4 from human leukocytes[J]. FEBS Letters, 1981, 130 1: Pages 107-112. DOI: 10.1016/0014-5793(81)80676-x
[2] T. HARPER R M M Garrity. Metabolism of leukotriene B4 in isolated rat hepatocytes. Identification of a novel 18-carboxy-19,20-dinor leukotriene B4 metabolite.[J]. The Journal of Biological Chemistry, 1986, 140 1: 5414-5418. DOI: 10.1016/s0021-9258(19)57231-3
[3] STEVEN J. FEINMARK. Stimulation of human leukocyte degranulation by leukotriene B4 and its ω-oxidized metabolites[J]. FEBS Letters, 1981, 136 1: Pages 141-144. DOI: 10.1016/0014-5793(81)81233-1