1-PHENYL-3-BUTEN-1-OL

clear colorless liquid

4-Phenyl-1-buten-4-ol is a building block that can be used in the synthesis of (R)-2,3-Dihydro-2-phenyl-4H-1-benzopyran-4-one (H447850), which is an impurity of Propafenone (P757500), a sodium channel blocker and an antiarrhythmic (class IC) compound.

ChEBI: 1-phenyl-3-buten-1-ol is an aromatic alcohol that is (but-3-en-1-yl)benzene in which one of the benzylic methylene hydrogens has been replaced by a hydroxy group. It is a secondary alcohol, an aromatic alcohol and an olefinic compound.

Chemistry Letters, 17, p. 2049, 1988
Journal of the American Chemical Society, 110, p. 4473, 1988 DOI: 10.1021/ja00221a091
Tetrahedron Letters, 30, p. 5413, 1989 DOI: 10.1016/S0040-4039(01)80581-5