Pyrafluprole has a melting point of 119-120°C. Its structure is characterized by the presence of a phenyl group on the central pyrazole ring, attached to one of the nitrogen atoms of the pyrazole, which makes it biologically active.
Pyrafluprole is an Insect GABA receptors.
ChEBI: Pyrafluprole is a member of the class of pyrazoles that is 1H-pyrazole which is substituted by a 2,6-dichloro-4-(trifluoromethyl)phenyl, nitrile, (fluoromethyl)sulfanediyl and [(pyrazin-2-yl)methyl]nitrilo groups at positions 1,3,4 and 5, respectively. It is an experimental insecticide introduced by Nihon Nohyaku Co Ltd, Japan. It is a phenylpyrazole insecticide, a dichlorobenzene, a member of (trifluoromethyl)benzenes, a nitrile and an organic sulfide.
Commercial production of pyrafluprole is not available in open literature. However, its structure is closely aligned with other phenylpyrazoles, so commercial synthesis would logically follow the standard sequence used for this class: construction of the 2,6 dichloro 4 trifluoromethylphenyl fragment, assembly of the multi substituted pyrazole core, and late stage introduction of the fluoromethylthio and pyrazinylmethyl nitrile substituents through controlled nucleophilic substitution and coupling reactions.
Works by blocking GABA-gated chloride channels in insects, leading to overexcitation of the nervous system and eventual death
