(R,?E)?-?(3-?Palmitamido-?4-?(4-?((4-?(2,?2,?2-?trifluoroethoxy)?pyridin-?2-?yl)?methoxy)?phenyl)?but-?1-?en-?1-?yl)?phosphonic Acid is used in developing phosphatase-resistant L-tyrosine derived VPC51098 that inhibited calcium release in human epithelial carcinoma cell, LPA receptor in Chinese hamster ovary cell and rat hepatoma, inhibited cAMP accumulation in rat glioma cell.