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CASTANOSPERMINE

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CASTANOSPERMINE Basic information
CASTANOSPERMINE Chemical Properties
  • Melting point:213-217 °C(lit.)
  • alpha D25 +79.7° (c = 0.93 in water)
  • Boiling point:421.9±45.0 °C(Predicted)
  • Density 1.53±0.1 g/cm3(Predicted)
  • storage temp. 2-8°C
  • solubility 1 M HCl: 20 mg/mL, clear, very faintly yellow
  • pka6.09(at 25℃)
  • form White solid
  • optical activity[α]20/D +80°, c = 0.9 in H2O
  • Water Solubility Soluble in water
  • Merck 13,1906
  • BRN 3588654
  • CAS DataBase Reference79831-76-8(CAS DataBase Reference)
Safety Information
MSDS
CASTANOSPERMINE Usage And Synthesis
  • Chemical PropertiesWhite Crystalline Solid
  • OccurrenceThe seeds of Castanospermum australe yield this simple alkaloid. It forms colourless crystals from EtOH and is dextrorotatory with a specific rotation of [α]D25 +79.7° (c 0.93, H20). Castano spermine has been characterized as the crystalline methiodide, m.p. 11O-112°C.
  • Usesa-L-fucosidases inhibitor
  • UsesCastanospermine is a plant alkaloid shown to be a potent inhibitor of lysosomal a-or beta- glucosidase. It also inhibits mammalian glucosidase 1 and beta-mannosidase from sweet almonds and fungal beta-xylosidase.
  • Biological ActivityPotent inhibitor of α - and β -glucosidases, especially glucosidase l (required for glucoprotein processing by transfer of mannose and glucose from asparagine-linked lipids). Inhibits HIV syncytium formation and replication.
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