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PHENMETRAZINE

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PHENMETRAZINE Basic information
PHENMETRAZINE Chemical Properties
  • Boiling point:bp12 138-140°; bp1 104°
  • Density 1.0290 (rough estimate)
  • refractive index 1.5302 (estimate)
  • pkapKa 8.45 (Uncertain)
  • EPA Substance Registry SystemMorpholine, 3-methyl-2-phenyl- (134-49-6)
Safety Information
PHENMETRAZINE Usage And Synthesis
  • OriginatorPreludin, Boehringer Ingelheim, US ,1956
  • UsesAnorexic.
  • DefinitionChEBI: A member of the class of morpholines that is morpholine substituted with a phenyl group at position 2 and a methyl group at position 3.
  • Manufacturing Process10 grams of β-phenyl-α-methyl-β,β'-dihydroxy-diethylamine hydrochloride (produced by hydrogenation in the presence of palladium and charcoal of βphenyl-α-methyl-β-keto-β'-hydroxy-N-benzyl-diethylamine hydrochloride obtained from bromopropiophenone by reacting with benzyl-ethanolamine), are warmed with 10% hydrochloric acid for 6 hours on a water bath.After working up in the usual manner, the hydrochloride of the 2-phenyl-3methyl-morpholine crystallizes out from methanolic hydrochloric acid and acetone, MP = 182°C, according to US Patent 2,835,669.
  • brand namePreludin (Boehringer Ingelheim);Anorex;Bromadryl;Emagrin;Filon;Gratsidin;Marsin;Neo-zine;Prelazine.
  • Therapeutic Function Antiobesity
  • World Health Organization (WHO)Phenmetrazine, a sympathomimetic amine, was introduced in 1956 for use as an anorexic agent. Although preparations remain available, the use of phenmetrazine is no longer indicated for the treatment of obesity. Moreover, since it has been subject to abuse, and because dependence can occur, it is now controlled under Schedule II of the 1971 Convention on Psychotropic Substances. (Reference: (UNCPS2) United Nations Convention on Psychotropic Substances (II), , , 1971)
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