ethyl 2-[(4-chlorophenyl)amino]-4-oxo-4,5-dihydrothiophene-3-carboxylate

KUN29943 is a Novel Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitor. This product has no formal name.

PfDHODH-IN-2, a dihydrothiophenone derivative (Compound 11), is a potent Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitor with an IC50 of 1.11 μM. PfDHODH-IN-2 acts as an antimalarial agent and can be used for the research of malaria[1].

[1] Minghao Xu, et al. Novel selective and potent inhibitors of malaria parasite dihydroorotate dehydrogenase: discovery and optimization of dihydrothiophenone derivatives. J Med Chem. 2013 Oct 24;56(20):7911-24. DOI:10.1021/jm400938g