6-Geranylnaringenin

Product Name6-Geranylnaringenin
CAS97126-57-3
MFC25H28O5
MW408.48682
EINECS
MOL File97126-57-3.mol

Chemical Properties

Melting point	116-118 °C
Boiling point	647.8±55.0 °C(Predicted)
Density	1.219±0.06 g/cm3(Predicted)
solubility	Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form	Cryst.
pka	7.62±0.40(Predicted)

Usage And Synthesis

Description

6-Geranylnaringenin is a natural product from Humulus lupulus.

Uses

Bonannione A (6-Geranylnaringenin; Mimulone), a prenylflavonoid, is an orally active and potent protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC50 of 14 μM. Bonannione A triggers caspase-dependent apoptosis. Bonannione A induces autophagy through p53-mediated AMPK/mTOR pathway. Bonannione A shows anti-inflammatory, antiradical and anti-cancer activity[1][2][3].

in vivo

Bonannione A (25 mg/kg; gavage; 48 and 24 h prior to DSS and every 24 h on the following days; for 5days) ameliorates the symptoms of colitis and delayed their onset^[3].

Animal Model:	Male Wistar rats (180-220 g)^[3]
Dosage:	25 mg/kg
Administration:	Gavage; 48 and 24 h prior to DSS (10% (w/v)) and every 24 h on the following days; for 5days
Result:	Ameliorated the symptoms of colitis and delayed their onset. Showed the low DAI on the last day of the experiment.

References

[1] Lai-Bin Zhang, et al. Isoprenylated Flavonoids with PTP1B Inhibition from Macaranga denticulate. Nat Prod Bioprospect. 2016 Feb;6(1):25-30. DOI:10.1007/s13659-015-0082-2
[2] Hyun-Kyu An, et al. Mimulone-induced autophagy through p53-mediated AMPK/mTOR pathway increases caspase-mediated apoptotic cell death in A549 human lung cancer cells. PLoS One. 2014 Dec 9;9(12):e114607. DOI:10.1371/journal.pone.0114607
[3] Zora Vochyánová, et al. Diplacone and mimulone ameliorate dextran sulfate sodium-induced colitis in rats. Fitoterapia. 2015 Mar;101:201-7. DOI:10.1016/j.fitote.2015.01.012