This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain, an OPR domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cytoplasmic protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. (provided by RefSeq)
PARD6B (par-6 family cell polarity regulator beta) gene encodes a member of the PAR6 family. It is an adapter protein th at functions in asymmetrical cell division and cell polarization processes. It may function in the formation of epithelial tight junctions. It forms a component of the PAR-atypical protein kinase C (aPKC) complex, which is a polarity protein complex involved in the polarization processes during epithelial morphogenesis, astrocyte migration, and axon specification. The gene is located in a region th at is often associated with breast cancer.
