Y16

Product NameY16
CAS429653-73-6
MFC24H20N2O3
MW384.43
EINECS
MOL File429653-73-6.mol

Chemical Properties

Density	1.273±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: soluble5mg/mL, clear (warmed)
pka	8.84±0.20(Predicted)
form	powder
color	, faint yellow to dark orange

Safety Information

Hazard Codes	N
Risk Statements	50/53
Safety Statements	60-61
RIDADR	UN 3077 9 / PGIII
WGK Germany	3

Usage And Synthesis

Biological Activity

Y16 is an inhibitor of G protein-coupled Rho GEFs. It blocks the binding of LARG and Rho with a Kd of 80 nM.

in vitro

Y16 (10-30 μΜ; 24 hours; NIH 3T3 cells) could inhibit RhoA-GTP formation induced by serum dose dependently and is specific for RhoA.
Y16 (10-30 μΜ; 24 hours ; NIH 3T3 cells) efficiently inhibits serum or SDF-1α-induced phospho-MLC and phospho-FAK formation, which are downstream of RhoA.

Cell Viability Assay

Cell Line:	NIH 3T3 cells
Concentration:	10 μΜ, 30 μΜ
Incubation Time:	24 hours
Result:	Inhibited RhoA-GTP formation induced by serum dose dependently and was specific for RhoA.

Western Blot Analysis

Cell Line:	NIH 3T3 cells
Concentration:	10 μΜ, 30 μΜ
Incubation Time:	24 hours
Result:	Inhibited serum or SDF-1α-induced phospho-MLC and phospho-FAK formation, which were downstream of RhoA.

target

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Target	Value
RhoGEFs ()