A 438079 (hydrochloride)
A 438079 (hydrochloride)
A 438079 (hydrochloride) 性质
| 储存条件 | -20°C |
|---|---|
| 溶解度 | 溶于DMSO(>25mg/ml) |
| 形态 | 固体 |
| 颜色 | 白色至类白色 |
| 稳定性 | 可在-20°C下的DMSO溶液保存长达1个月。 |
| InChI | 1S/C13H9Cl2N5.ClH.H2O/c14-11-5-1-4-10(12(11)15)13-17-18-19-20(13)8-9-3-2-6-16-7-9;;/h1-7H,8H2;1H;1H2 |
| InChIKey | ZHFJJBAKSROKNO-UHFFFAOYSA-N |
| SMILES | O.Cl.Clc1cccc(c1Cl)-c2nnnn2Cc3cccnc3 |
A 438079 (hydrochloride) 用途与合成方法
pIC50: 6.9
In 1321N1 cells stably expressing rat P2X 7 receptors, A 438079 blocks BzATP-(10 μM) evoked changes in intracellular calcium concentrations with an IC 50 of 321 nM. A 438079 is also selective for the P2X 7 receptor, at concentrations up to 100 μM.
A 438079 (80 μmol/kg, i.v.) reduces noxious and innocuous evoked activity of different classes of spinal neurons in neuropathic rats. A 438079 (100 and 300 μmol/kg, i.p.) significantly raises withdrawal thresh-olds in both the SNL and CCI models. Intraperitoneal injection of A 438079 (5 and 15 mg/kg) 60 min after triggering seizures reduces seizure severity and neuronal death within the hippocampus. A 438079 has superior neuroprotective effects compared with an equally dose of phenobarbital (25 mg/kg). A 438079 partially but significantly prevents the 6-OHDA-induced depletion of striatal DA stores. Pretreatment with A 438079 reduces nociceptive behaviour scores in the HC model.
A 438079 (hydrochloride) 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026-09-15 | HY-15488AR | A 438079 (hydrochloride) | 899431-18-6 | 5 mg | 1555 |
| 2026-09-15 | HY-15488A | A 438079 (hydrochloride) | 899431-18-6 | 1 mg | 316 |
