FP Receptor Polyclonal Antibody

The prostaglandin F_2α receptor (FP receptor) is a G protein-coupled receptor known to elicit smooth muscle contraction in a variety of tissues. FP receptor mRNA is found in reproductive, gastric, neural, and ocular tissues as well as specialized cells of the kidney. Two FP receptor isoforms, FPA and FPB have been identified in sheep. FPB receptor is truncated at the carboxy-terminus thereby preventing desensitization (which normally occurs by protein kinase C phosphorylation of FPA) and produces aberrant signalling in FPB transfectants. The existence of a truncated human FP isoform responsible for signal-amplification contributing to luteolysis, cell growth, or malignant transformation is currently unknown. Cayman’s FP Receptor Polyclonal Antibody can be used for Western blot applications. The calculated size of FP Receptor is 41 kDa and this antibody recognizes multiple bands from 50-67 kDa from human, bovine, mouse, ovine, and rat samples.

[1] S NARUMIYA  F U  Y Sugimoto. Prostanoid receptors: structures, properties, and functions.[J]. Physiological reviews, 1999, 79 4: 1193-1226. DOI: 10.1152/physrev.1999.79.4.1193
[2] MARK ABRAMOVITZS. Cloning and expression of a cDNA for the human prostanoid FP receptor.[J]. The Journal of Biological Chemistry, 1994, 18 1: 2632-2636. DOI: 10.1016/s0021-9258(17)41991-0
[3] S. LAKE . Cloning of the rat and human prostaglandin F2α receptors and the expression of the rat prostaglandin F2α receptor[J]. FEBS Letters, 1994, 355 3: Pages 317-325. DOI: 10.1016/0014-5793(94)01198-2
[4] JUN-ICHI KITANAKA. Cloning and expression of a cDNA for rat prostaglandin F2α receptor[J]. Prostaglandins, 1994, 48 1: Pages 31-41. DOI: 10.1016/0090-6980(94)90094-9
[5] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
[6] K L PIERCE. Cloning of a carboxyl-terminal isoform of the prostanoid FP receptor.[J]. The Journal of Biological Chemistry, 1997, 272 2: 883-887. DOI: 10.1074/jbc.272.2.883
[7] H FUJINO. Differential regulation of prostaglandin F(2alpha) receptor isoforms by protein kinase C.[J]. Molecular Pharmacology, 2000, 57 2: 353-358.
[8] H. FUJINO J R. FP Prostanoid Receptor Activation of a T-cell Factor/β-Catenin Signaling Pathway*[J]. The Journal of Biological Chemistry, 2001, 107 1: 12489-12492. DOI: 10.1074/jbc.c100039200