General procedure for the synthesis of 6-chloro-4-amino pyridazine from 3,5-dichloropyridazine: 3,5-dichloropyridazine (1 g, 6.71 mmol, 1.0 eq.), ammonia (8 mL), and dioxane (2 mL) were added to a 25 mL round-bottom flask. The reaction mixture was stirred at 100 °C overnight. Upon completion of the reaction, the resulting solid was collected by filtration. A final 570 mg (62% yield) of 6-chloro-4-aminopyridazine was obtained as a brown solid. The product was analyzed by LC-MS to confirm: (ES, m/z): retention time (RT) = 0.434 min, LCMS purity 53%, m/z = 130 [M + 1].
