N6-(2-Hydroxyethyl)adenosine (20-40 mg/kg, ip, once daily for 6 weeks) reduces the blood glucose level and diabetes-induced kidney damage, increases the activities of antioxidant enzymes (such as SOD, catalase CAT and GSH) in renal tissue, reduces the level of malondialdehyde (MDA), exhibits anti-inflammatory and antioxidant activities, and ameliorates Alloxan (HY-W017227)-induced diabetes in rats models[2].
N6-(2-Hydroxyethyl)adenosine (75-150 mg/kg, po, once daily for 19 days) exhibits antitumor effect in SGC-7901 xenograft mouse models[4].
| Animal Model: | Alloxan-induced diabetes in rats models[2] |
| Dosage: | 20-40 mg/kg |
| Administration: | ip, once daily for 6 weeks |
| Result: | Reduced the levels of blood glucose, serum creatinine (Scr), blood urea nitrogen (BUN) and urine protein.
Reduced the levels of TNF-α, IL-1β, IL-6, TGF-β1 and NF-κB in kidney tissue.
Alleviated the damage of glomeruli and renal tubules.
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| Animal Model: | SGC-7901 xenograft mouse models[4] |
| Dosage: | 75-150 mg/kg |
| Administration: | po, once daily for 19 days |
| Result: | Reduced tumor volume and weight. |
