The chemical feat that perhaps best illustrates Angeli's intuitive talent was the discovery more than a century ago of the sodium salt of nitroxylaminic acid, also called Angeli's Salt (Na2N2O3). Na2[ON=NO2] is regarded as a classic nitroxyl(N=O-) donor, but under certain conditions evolution of NO is also observed. Angelo Angeli found that'salts of nitroxylaminic acid are readily resolved into the corresponding nitrites and the unsaturated nitroxyl residue. Angeli suggested their use as possible in vitro and in vivo sources of HNO,but physiological properties of this molecule didn't attract very much attention until the end of the 20th century.
Angeli's salt can be conveniently synthesized by treating hydroxylamine hydrochloride with excess sodium hydroxide,yielding hydroxylamine，which is further treated with butyl nitrate to produce the salt as a white solid.
Sodium Oxyhyponitrite is used in the treatment for hemolysis.
HNO/NO- donor in biochemical model studies.
A nitroxyl anion (NO–) donor that spontaneously dissociates in a pH dependent first order process to liberate 0.54 moles of NO per mole of the parent compound. Half-life (t) in 100 mM phosphate buffer, pH 7.4 is 2.3 minutes at 37°C. Decomposition is nearly instantaneous at pH 5.0.
Primary TargetNitroxyl anion (NO-) donor
