2-HYDROXY-5-METHYLISOPHTHALALDEHYDE

light yellow to beige cryst. powder or needles

2-Hydroxy-5-methyl-1,3-benzenedicarboxaldehyde (2-hydroxy-5-methylisophthalaldehyde) is suitable reagent used in the synthesis of 2-(2′-vinyloxyethoxy)-5-methylisophthaldehyde and chiral calixsalen macrocycles.
2-Hydroxy-5-methyl-1,3-benzenedicarboxaldehyde may be used in the synthesis of the following:

• 3-[(2,4-Dichlorophenyl)iminomethyl]-2-hydroxy-5-methylbenzaldehyde, a Schiff base.
• 2-Hydroxy-3-methoxymethyl-5-methylbenzaldehyde.
• Acyclic Schiff-base ligands.
• Macrobicyclic ligands (MSB).
• 4-Methyl-2,6-divinylphenol.
• 2-Hydroxy-3-dimethoxymethyl-5-methylbenzaldehyde.

2-Hydroxy-5-methyl-1,3-benzenedicarboxaldehyde (2-hydroxy-5-methylisophthalaldehyde) is a dialdehyde derivative. It has been synthesized by heating p-cresol with hexamethylenetetramine. The structure has been confirmed by ¹H and ¹³C NMR. It is an important raw material for the synthesis of various binucleating schiff base ligand.